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Cat. No.: HY-189407

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AChE/BChE-IN-42

AChE/BChE-IN-42 is a potent competitive inhibitor of AChE and BChE, with K_i values of 24.27 nM and 81.89 nM, respectively. AChE/BChE-IN-42 binds tightly to the active sites (CAS and PAS) of AChE and BChE through multiple strong interactions, thereby competitively inhibiting the activity of both cholinesterases. AChE/BChE-IN-42 can be used for research on Alzheimer's disease.

For research use only. We do not sell to patients.

Formula: C₂₈H₂₉F₃N₄O₄
Molecular Weight:542.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AChE/BChE-IN-42 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

AChE

24.27 nM (Ki)

BChE

81.89 nM (Ki)

All Cholinesterase (ChE) Isoforms :

AChE
BChE

Cellular Effect

Cell Line	Type	Value	Description	References
SH-SY5Y	IC₅₀	37.32 μM	Cytotoxicity against human neuroblastoma SH-SY5Y cells assessed as reduction in cell viability incubated for 24 hrs by crystal violet staining method. Cytotoxicity against human neuroblastoma SH-SY5Y cells assessed as reduction in cell viability incubated for 24 hrs by crystal violet staining method.	42585890

In Vitro

AChE-IN-121 (200-3.125 μM; 24 h) shows low cytotoxicity against human neuroblastoma SH-SY5Y cells with an IC₅₀ of 37.32 μM^[1].
AChE-IN-121 is a potent competitive inhibitor of Electrophorus electricus AChE with a K_i of 24.27 nM and demonstrates selectivity for AChE over BChE^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

SH-SY5Y
Concentration:

3.125, 6.25, 12.5, 25, 50, 100, 200 μM
Incubation Time:

24 h
Result:

Exhibited low cytotoxicity toward SH-SY5Y cells with an IC₅₀ value of 37.32 μM.

Related Protocols :

Chemical Information

Molecular Weight 542.55
Formula C₂₈H₂₉F₃N₄O₄
SMILES

COC1=CC(/C=N/NC(C2=CC=C(C=C2)OC3=NC=CC=C3C(F)(F)F)=O)=CC(CN4CC(C)CCC4)=C1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Şenol H, et al. Development of novel diaryl ether-phenolic Mannich Base derivatives with potent cholinesterase inhibition and low neuronal toxicity. Bioorganic chemistry. 2026 Oct 05;181:110354.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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