AChE/BuChE-IN-9
AChE/BuChE-IN-9 is a dual Cholinesterase inhibitor that acts on electric eel acetylcholinesterase (AChE) (IC50 = 14.82 μM) and horse serum butyrylcholinesterase (IC50 = 27.91 μM) through non-competitive and mixed-mode inhibition, respectively. AChE/BuChE-IN-9 can be used for research on Alzheimer's disease.
For research use only. We do not sell to patients.
- Formula: C18H20N2O4
- Molecular Weight:328.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
AChE 14.82 μM (IC50) |
BuChE 27.91 μM (IC50) |
In Vitro
AChE/BuChE-IN-9 acts as a non-competitive inhibitor of AChE (Ki = 1.522 μM) and a mixed-type inhibitor of BuChE (Ki = 0.6550 μM)[1].
AChE/BuChE-IN-9 possesses the optimal HOMO-LUMO energy gap (4.287 eV) and a moderate electrophilicity index (2.923 eV), which correlate with its cholinesterase inhibitory activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 328.36
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Formula C18H20N2O4
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SMILES
OC1=CC=C(/C(C)=N\N=C\C2=CC(OC)=C(OC)C(OC)=C2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE/BuChE-IN-9 Related Classifications
HY-189483 Related Classifications
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