country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-N21682

Copy Link Print Information

Adhumulone

Adhumulone is an α-acid derived from hops and a selective AKR1B10 inhibitor, with IC₅₀ values of 5.41-29.27 μM and K_i values of 3.27-16.79 μM against human AKR1B10. Adhumulone inhibits AKR1B10-mediated reduction of Farnesol (HY-Y0248A) as a competitive inhibitor, and it also suppresses the reduction of DL-Glyceraldehyde (HY-128748) and Farnesal substrates. Adhumulone is useful for research on ras-dependent malignancies.

For research use only. We do not sell to patients.

CAS No.: 31769-65-0
Formula: C₂₁H₃₀O₅
Molecular Weight:362.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Adhumulone Chemical Structure

CAS No.: 31769-65-0

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]^[2]

AKR1B10

5.41-29.27 μM (IC₅₀)

AKR1B10

3.27-16.79 μM (Ki)

In Vitro

Adhumulone (Compound 1) selectively inhibits recombinant human AKR1B10 when DL-Glyceraldehyde (HY-128748) is used as the substrate, with an IC₅₀ of 5.41 µM and a K_i value of 3.27 μM, while its activity against AKR1A1 and AKR1B1 is much weaker^[1].
Adhumulone acts as a competitive inhibitor of recombinant human AKR1B10-mediated reduction of Farnesol (HY-Y0248A), with an IC₅₀ of 29.27 µM and a K_i of 16.79 µM^[1].
Adhumulone (41c) is a major α-acid sensory metabolite in fresh Humulus lupulus L. hop pellets, with concentrations ranging from 5-15% across 75 commercial hop varieties^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 31769-65-0
Molecular Weight 362.46
Formula C₂₁H₃₀O₅
SMILES

O=C(C(CC)C)C(C(O)=C1C/C=C(C)\C)=C(O)C(O)(C/C=C(C)\C)C1=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Seliger JM, et al. Selective Inhibition of Human AKR1B10 by n-Humulone, Adhumulone and Cohumulone Isolated from Humulus lupulus Extract. Molecules. 2018 Nov 21;23(11):3041.

[2]. Dresel M, et al. The Bitter Chemodiversity of Hops (Humulus lupulus L.). Journal of agricultural and food chemistry. 2016;64(41):7789-7799. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote