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Cat. No.: HY-P990876A

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Afimkibart

Name: Afimkibart
Brand: MedChemExpress
SKU: HY-P990876A
Availability: PreOrder

(Synonyms: PF-06480605; RVT-3101)

Afimkibart (PF-06480605; RVT-3101) is a humanized monoclonal antibody targeting TL1A (TNFSF15). Afimkibart blocks the TL1A‑DR3 signaling axis by neutralizing the TL1A ligand, inhibits the release of pro-inflammatory cytokines, suppresses NF-κB activation and IFN-γ production, and simultaneously attenuates fibroblast activation and fibrosis progression associated with this pathway. The Fc region of Afimkibart contains the mutations L234A, L235A, and G237A, which are designed to reduce the binding of the antibody to FcγR and C1q, thereby attenuating or eliminating the antibody’s ADCC and CDC effector functions. Afimkibart is applicable to research on immune inflammation-related conditions, such as ulcerative colitis.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Afimkibart Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

^[1]

NF-κB

All TNF Receptor Isoforms :

All NF-κB Isoforms :

In Vitro

Afimkibart selectively binds to functional trimeric TL1A but not to monomeric TL1A. It neutralizes trimeric TL1A, inhibits TL1A-induced NF-κB activation in human peripheral blood T lymphocytes, and suppresses IFN-γ secretion stimulated by trimeric TL1A in combination with IL-12/IL-18 in human peripheral blood mononuclear cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Afimkibart (subcutaneous administration/intravenous administration) generates signals associated with clinical remission under study conditions related to moderate-to-severe active ulcerative colitis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Gene ID

9966 [NCBI]

Accession

O95150

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Application

ELISA, FACS, Functional assay

Chemical Information

SMILES

[Afimkibart]
Synonyms

PF-06480605; RVT-3101
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Kitsou K, et al. The Therapeutic Potential of Targeting TL1A in a Spectrum of Inflammatory Disorders. Journal of inflammation research. 2026;19:546272.

[2]. Goyal MK, et al. Review Article: TL1A Inhibitors in IBD - Mechanistic Rationale and Clinical Evidence. Alimentary pharmacology & therapeutics. 2026 Jun;63(11):1458-1473. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Application
Chemical Information
Purity & Documentation
References

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Afimkibart

All TNF Receptor Isoforms

All NF-κB Isoforms