Ajmalicine hydrochloride
Based on 3 publication(s) in Google Scholar
Ajmalicine (Raubasine) hydrochloride is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine hydrochloride is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine hydrochloride also can be used as anti-hypertensive, and serpentine, with sedative activity.
For research use only. We do not sell to patients.
- CAS No.: 4373-34-6
- Formula: C21H25ClN2O3
- Molecular Weight:388.89
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ajmalicine hydrochloride
MoreAll Adrenergic Receptor Isoforms
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Biological Activity
Description
IC50 & Target
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α1-adrenergic receptor |
α2-adrenergic receptor |
In Vitro
Ajmalicine hydrochloride preferentially blocks α1-adrenoceptor than α2-adrenoceptor[1].
Ajmalicine hydrochloride inhibits contractions in a concentration-dependent manner (IC50=72.3 ± 22.5 μM)[2].
Ajmalicine hydrochloride acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Ajmalicine hydrochloride (0.5-4 mg/kg) induces a marked dose-dependent inhibition against the pressor response to noradrenaline[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (300-350 g)[1]
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Dosage:0.5, 1, 2, and 4 mg/kg
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Administration:IV, once
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Result:Induced a marked dose-dependent inhibition against the pressor response to noradrenaline.
Chemical Information
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CAS No. 4373-34-6
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Molecular Weight 388.89
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Formula C21H25ClN2O3
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SMILES
O=C(C1=CO[C@@H](C)[C@](CN2CC3)([H])[C@]1([H])C[C@@]2([H])C4=C3C5=CC=CC=C5N4)OC.[H]Cl
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Synonyms
Raubasine hydrochloride
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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J Biochem Mol Toxicol
2024 Jan;38(1):e23614. PMID: 38064316
Purity & Documentation
References
[1]. Roquebert J, et al. Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine. Eur J Pharmacol. 1984 Oct 30;106(1):203-5. [Content Brief]
[2]. Pereira DM, et al. Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission. Phytomedicine. 2010 Jul;17(8-9):646-52. [Content Brief]
[3]. Demichel P, et al. Effects of raubasine stereoisomers on pre- and postsynaptic alpha-adrenoceptors in the rat vas deferens. Br J Pharmacol. 1984 Oct;83(2):505-10 [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ajmalicine hydrochloride Related Classifications
HY-N1919A Related Classifications
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