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Cat. No.: HY-137081

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AKOS024836912

AKOS024836912 is a EGFR-EGF interaction inhibitor. AKOS024836912 is applicable to research related to non-small cell lung cancer.

For research use only. We do not sell to patients.

CAS No.: 1705763-81-0
Formula: C₁₈H₂₃N₅O₂
Molecular Weight:341.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AKOS024836912 Chemical Structure

CAS No.: 1705763-81-0

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

AKOS024836912 is a EGFR-EGF interaction inhibitor. AKOS024836912 is applicable to research related to non-small cell lung cancer^[1].

All EGFR Isoforms :

In Vitro

AKOS024836912 exhibits higher binding affinity to the EGF-binding cleft of EGFR (PDB ID: 1NQL) than its parent compound Dacomitinib (HY-13272), with a rearrangement score of -114.109^[1].
AKOS024836912 inhibits the interaction between EGFR (PDB ID: 1NQL) and EGF, with a PatchDock score of 6115^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1705763-81-0
Molecular Weight 341.41
Formula C₁₈H₂₃N₅O₂
SMILES

O=C(NC1=NC=NC(N2CCCCC2)=C1)NC3=CC(C)=CC=C3OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gudala S, et al. Identification and Pharmacological Analysis of High Efficacy Small Molecule Inhibitors of EGF-EGFR Interactions in Clinical Treatment of Non-Small Cell Lung Carcinoma: a Computational Approach. Asian Pacific journal of cancer prevention : APJCP. 2015;16(18):8191-6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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