country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-189728

Copy Link Print Information

AKT1 ligand-1

AKT1 ligand-1 is an AKT1 ligand. AKT1 ligand-1 exhibits anticancer activity against prostate cancer, lung cancer, and breast cancer.

For research use only. We do not sell to patients.

Formula: C₂₁H₂₃ClN₄O₂S
Molecular Weight:430.95

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AKT1 ligand-1 Chemical Structure

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

AKT1 ligand-1 is an AKT1 ligand. AKT1 ligand-1 exhibits anticancer activity against prostate cancer, lung cancer, and breast cancer^[1].

IC₅₀ & Target

^[1]

Akt1

All Akt Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
PC-3	IC50	16.12 μM	Cytotoxicity against human PC3 prostate adenocarcinoma cells measured by MTT assay after 24 hrs incubation. Cytotoxicity against human PC3 prostate adenocarcinoma cells measured by MTT assay after 24 hrs incubation.	s41598-026-67079-8
A549	IC50	26.36 μM	Cytotoxicity against human A549 lung carcinoma cells measured by MTT assay after 24 hrs incubation. Cytotoxicity against human A549 lung carcinoma cells measured by MTT assay after 24 hrs incubation.	s41598-026-67079-8
MCF7	IC50	19.12 μM	Cytotoxicity against human MCF-7 breast adenocarcinoma cells measured by MTT assay after 24 hrs incubation. Cytotoxicity against human MCF-7 breast adenocarcinoma cells measured by MTT assay after 24 hrs incubation.	s41598-026-67079-8

In Vitro

Anti-cancer

AKT1 ligand-1 (Compound 4b) (6.25-100 µM; 24 h) exhibits MTT cytotoxicity against PC3, A549, and MCF-7 cancer cell lines, with IC₅₀ values of 16.12, 26.36, and 19.12 µM, respectively, showing the strongest activity against PC3 prostate adenocarcinoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

PC3, A549, and MCF-7 human cancer cell lines
Concentration:

6.25-100 µM
Incubation Time:

24 h
Result:

IC50 values for AKT1 ligand-1 (compound 4b) were 16.12 µM against PC3, 26.36 µM against A549, and 19.12 µM against MCF-7.
AKT1 ligand-1 (compound 4b) showed 1.6-fold higher potency against PC3 compared with A549.

Related Protocols :

Breast Cancer Modeling

Chemical Information

Molecular Weight 430.95
Formula C₂₁H₂₃ClN₄O₂S
SMILES

C=C([C@@H]1CC=C(/C(C1)=N/N=C2SC(C(OCC)=O)=NN/2C3=CC=C(C=C3)Cl)C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Al-Saleem M S M, et al. Synthesis and in silico assessment of thiadiazole scaffolds for anticancer applications: network pharmacology and molecular simulations[J]. Scientific Reports, 2026.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote