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Cat. No.: HY-14246

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ALK-IN-38

Anaplastic Lymphoma Kinase Inhibitor.

For research use only. We do not sell to patients.

CAS No.: 1022957-12-5
Formula: C₂₅H₂₉ClN₆O₃
Molecular Weight:496.99

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ALK-IN-38 Chemical Structure

CAS No.: 1022957-12-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

Anaplastic Lymphoma Kinase Inhibitor

Cellular Effect

Cell Line	Type	Value	Description	References
KARPAS-299	EC₅₀	200 nM Compound: 15	Growth inhibition of ALK-positive human KARPAS299 cells by MTS assay Growth inhibition of ALK-positive human KARPAS299 cells by MTS assay	[PMID: 24900237]
KARPAS-299	IC₅₀	225 nM Compound: 15	Inhibition of NPM-ALK autophosphorylation in human KARPAS299 cells in presence of mouse plasma Inhibition of NPM-ALK autophosphorylation in human KARPAS299 cells in presence of mouse plasma	[PMID: 24900237]
KARPAS-299	IC₅₀	45 nM Compound: 15	Inhibition of NPM-ALK autophosphorylation in human KARPAS299 cells Inhibition of NPM-ALK autophosphorylation in human KARPAS299 cells	[PMID: 24900237]
KARPAS-299	IC₅₀	45 nM Compound: 3	Inhibition of ALK tyrosine phosphorylation in human Karpas-299 cells after 2 hrs in presence of mouse plasma Inhibition of ALK tyrosine phosphorylation in human Karpas-299 cells after 2 hrs in presence of mouse plasma	[PMID: 22564207]

Chemical Information

CAS No. 1022957-12-5
Molecular Weight 496.99
Formula C₂₅H₂₉ClN₆O₃
SMILES

NC([C@H]1[C@@](C=C2)([H])C[C@@]2([H])[C@H]1NC3=NC(NC4=CC=C(N(C(CCC5)=O)CC)C5=C4OC)=NC=C3Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Discovery of a Potent Inhibitor of Anaplastic Lymphoma Kinase with in Vivo Antitumor Activity ACS Med. Chem. Lett., Article ASAP DOI: 10.1021/ml100158s Publication Date (Web): September 1, 2010

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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