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Cat. No.: HY-189400

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α-Amylase Ligand 1

α-Amylase Ligand 1 is a human pancreatic α-amylase binder with a K_d of 53.55 μM. α-Amylase Ligand 1 binds within the catalytic site through hydrogen bonding and hydrophobic interactions with active site residues. α-Amylase Ligand 1 is predicted to be orally active with a good safety profile. α-Amylase Ligand 1 can be used for diabetes-related research.

For research use only. We do not sell to patients.

CAS No.: 77491-07-7
Formula: C₁₄H₁₁Cl₂NO
Molecular Weight:280.15

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

α-Amylase Ligand 1 Chemical Structure

CAS No.: 77491-07-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
3T3-L1	IC50	375.34 μg/mL	Cytotoxicity against mouse 3T3-L1 preadipocytes assessed as reduction in cell viability after 24 hrs of compound exposure by MTT assay. Cytotoxicity against mouse 3T3-L1 preadipocytes assessed as reduction in cell viability after 24 hrs of compound exposure by MTT assay.	42543020

In Vitro

α-Amylase Ligand 1 (compound (I)) (30 min) binds to α-amylase with a dissociation constant (K_d) of 53.55 μM^[1].
α-Amylase Ligand 1 (25-250 μg/mL; 24 h) exhibits low cytotoxicity against 3T3-L1 cells with an IC₅₀ of 375.34 μg/mL^[1].
The predicted ADME/toxicity profile of α-Amylase Ligand 1 indicates oral absorption potential, possible BBB penetration, non-mutagenicity, and non-hepatotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

3T3-L1 mouse adipocyte cell line
Concentration:

25, 50, 75, 100, 125, 150, 175, 200, 225 and 250 μg/mL
Incubation Time:

24 h
Result:

Reduced cell viability in a dose-dependent manner.
Achieved 76.02% cell viability at 250 μg/mL.
Showed an IC₅₀ of 375.34 μg/mL.

Related Protocols :

Research Protocol for Metabolic Diseases

Chemical Information

CAS No. 77491-07-7
Molecular Weight 280.15
Formula C₁₄H₁₁Cl₂NO
SMILES

OC1=CC=C(C)C=C1/N=C/C2=CC=C(Cl)C=C2Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chakkarapani N, et al. Design, synthesis, and biological evaluation of a dichloro-substituted schiff base as an α-amylase inhibitor: structural, computational, and molecular dynamics, approaches. Journal of biomolecular structure & dynamics. 2026 Aug 02.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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