country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-189093

Copy Link Print Information

αvβ5 integrin-IN-3

αvβ5 integrin-IN-3 is an orally active, selective αVβ5 integrin inhibitor with an IC₅₀ value of 0.61 nM. αvβ5 integrin-IN-3 inhibits αVβ1, αVβ3 and αVβ6 integrins with IC₅₀ values of 21 nM, 5.5 nM and 18 nM, respectively. αvβ5 integrin-IN-3 reduces total Collagen content in a mouse unilateral ureteral obstruction model. αvβ5 integrin-IN-3 can be used for the research of renal fibrosis.

For research use only. We do not sell to patients.

CAS No.: 2226557-15-7
Formula: C₂₂H₂₆N₆O₂
Molecular Weight:406.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

αvβ5 integrin-IN-3 Chemical Structure

CAS No.: 2226557-15-7

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

αvβ5

0.61 nM (IC₅₀)

αvβ1

21 nM (IC₅₀)

αvβ3

5.5 nM (IC₅₀)

αvβ6

18 nM (IC₅₀)

αvβ8

2490 nM (IC₅₀)

αIIbβ3

186 nM (IC₅₀)

All Integrin Isoforms :

In Vitro

αvβ5 integrin-IN-3 (Compound 14) potently inhibits human αVβ6, αVβ1, αVβ3, and αVβ5 integrins with IC₅₀ values ranging from 0.61 nM to 21 nM, and exhibits high selectivity over human αVβ8 and αIIbβ3 integrins^[1].
αvβ5 integrin-IN-3 has reduced plasma protein binding across rat, mouse, and cynomolgus monkey plasma, with free fractions ranging from 9.0% to 21%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	CL	V_ss	T_1/2	AUC_all	C_max	T_max	Bioavailability
Mice^[1]	1 mg/kg	i.v.	8.1 mL/min/kg	0.6 L/kg	0.9 h	5.1 μM·h	/	/	/
Mice^[1]	10 mg/kg	p.o.	/	/	/	44 μM·h	12.5 μM	1 h	88 %

In Vivo

Renal Regulation

αvβ5 integrin-IN-3 (10 mg/kg; p.o.; daily; 8 days) reduces kidney fibrosis in a mouse unilateral ureteral obstruction model by 25% via collagen reduction and suppression of pro-fibrotic gene expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 (female)^[1]
Dosage:

10 mg/kg
Administration:

p.o.; daily; 8 days
Result:

Reduced total kidney collagen content by 25% versus vehicle.
Reduced kidney expression of pro-fibrotic genes including Col1a1, Col3a1, fibronectin, and α-SMA.
Measured mean trough plasma concentration of 25 nM 16 hours after the final dose, corresponding to an estimated mean free concentration of 8.9 nM.

Related Protocols :

Chemical Information

CAS No. 2226557-15-7
Molecular Weight 406.48
Formula C₂₂H₂₆N₆O₂
SMILES

OC(C[C@@H](C1=CN=C(C)N=C1)N2C=CC(CCCC3=NC(NCCC4)=C4C=C3)=N2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhao G, et al. Discovery of Pyrazole-Containing RGD Mimics with Anti-Fibrotic Efficacy in the Unilateral Ureteral Obstruction Mouse Model. Journal of medicinal chemistry. 2026 Aug 13;69(15):18099-18116. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote