country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-178700

Copy Link Print Information

ALV-05-151-02

ALV-05-151-02 is a BCL6B zinc finger protein degrader that selectively targets BCL6B over BCL6. ALV-05-151-02 redirects the E3 ubiquitin ligase CRL4_CRBN to induce BCL6B degradation and interacts with the H357 residue of BCL6B.

For research use only. We do not sell to patients.

CAS No.: 2744249-11-2
Formula: C₂₇H₂₈F₃N₅O₄
Molecular Weight:543.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

ALV-05-151-02 Chemical Structure

CAS No.: 2744249-11-2

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

BCL6B

In Vitro

ALV-05-151-02 (18 h) selectively induces degradation of the BCL6B ZF reporter in U937 cells, but not the BCL6 ZF reporter, due to favorable interactions between BCL6B H357 and the compound's tertiary amine group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2744249-11-2
Molecular Weight 543.54
Formula C₂₇H₂₈F₃N₅O₄
SMILES

CN(C)C(CC(NC1=CC=CC(C(F)(F)F)=C1)=O)C2=CC(NC3=CCN(C4C(NC(CC4)=O)=O)C3=O)=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Słabicki M, et al. Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation. Molecular cell. 2025 Aug 21;85(16):3184-3201.e14. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote