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Cat. No.: HY-113104

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Androsterone glucuronide

Name: Androsterone glucuronide
Brand: MedChemExpress
SKU: HY-113104
Price: 491.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: ADT-G)

Androsterone glucuronide (ADT-G) is a major phase II glucuronidated metabolite of androgens (such as testosterone and dihydrotestosterone) in the human body and can be found in urine. Androsterone glucuronide levels can reflect the absorption and hepatic metabolism of testosterone. Androsterone glucuronide can be used in research on hirsutism, polycystic ovary syndrome, and moderate acne.

For research use only. We do not sell to patients.

CAS No.: 1852-43-3
Formula: C₂₅H₃₈O₈
Molecular Weight:466.56

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Androsterone glucuronide Chemical Structure

CAS No.: 1852-43-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

In Vitro

Androsterone glucuronide (ADT-G) can be specifically and efficiently catalyzed and synthesized from the substrate ADT in HEK293 cells stably expressing mouse Ugt2b37 and in male mouse kidney homogenates^[3].
Androsterone glucuronide can be generated from the substrate androsterone (ADT) catalyzed by recombinant mouse Ugt2b37 and male mouse kidney microsomes, with K_m values of 3.6 μM and 2.3 μM, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Androsterone glucuronide is not detectable in adult rat plasma^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1852-43-3
Appearance Solid
Molecular Weight 466.56
Formula C₂₅H₃₈O₈
Color White to off-white
SMILES

C[C@@]12[C@@]3([C@]([H])([C@]4([C@@](C(CC4)=O)(CC3)C)[H])CC[C@]1(C[C@@H](CC2)O[C@@]5(O[C@H](C(O)=O)[C@H]([C@@H]([C@H]5O)O)O)[H])[H])[H]
Synonyms

ADT-G
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Guillemette CH, et al. Levels of plasma C19 steroids and 5 alpha-reduced C19 steroid glucuronides in primates, rodents, and domestic animals. American Journal of Physiology-Endocrinology and Metabolism. 1996 Aug 1;271(2):E348-53.

[2]. Bélanger A, et al. Characterization and regulation of UDP-glucuronosyltransferases in steroid target tissues. The Journal of steroid biochemistry and molecular biology. 1998 Apr;65(1-6):301-10.

[3]. Grosse L, et al. Androgen Glucuronidation in Mice: When, Where, and How. Biology. 2022 Mar 05;11(3):403.

[4]. Qin X, et al. New insights into the androgen biotransformation in prostate cancer: A regulatory network among androgen, androgen receptors and UGTs. Pharmacological research. 2016 Apr;106:114-122.

[5]. Kaminski RM, et al. Anticonvulsant activity of androsterone and etiocholanolone. Epilepsia. 2005 Jun;46(6):819-27. [Content Brief]

[6]. Ponzetto F, et al. Single-run UHPLC-MS/MS method for simultaneous quantification of endogenous steroids and their phase II metabolites in serum for anti-doping purposes. Talanta. 2023 Apr 01;255:124218.

[7]. Cho LW, et al. Androsterone glucuronide to dehydroepiandrosterone sulphate ratio is discriminatory for obese Caucasian women with polycystic ovary syndrome. BMC endocrine disorders. 2017 May 19;17(1):26.

[8]. Carmina E, et al. The association of serum androsterone glucuronide with inflammatory lesions in women with adult acne. Journal of endocrinological investigation. 2002 Oct;25(9):765-8.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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