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Cat. No.: HY-189310

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Anti-inflammatory agent-123

Anti-inflammatory agent-123 is an anti-inflammatory agent. Anti-inflammatory agent-123 inhibits NF-κB signaling pathway activation and the secretion of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6). Anti-inflammatory agent-123 inhibits NO production. Anti-inflammatory agent-123 can be used for inflammation research.

For research use only. We do not sell to patients.

Formula: C₂₃H₁₆N₂O
Molecular Weight:336.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anti-inflammatory agent-123 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

IL-6

IL-1β

All NF-κB Isoforms :

All TNF Receptor Isoforms :

All Interleukin Related Isoforms :

All NO Synthase Isoforms :

In Vitro

Innate ImmunityCytokines & ChemokinesCytokines and ChemokinesOthers

Innate Immunity

Cytokines & Chemokines

Anti-inflammatory agent-123 (Compound 3h) (5-20 μM; 2 h) effectively inhibits LPS-induced NO production in RAW264.7 cells, with an inhibition rate of 95.37% at 20 μM^[1].
Anti-inflammatory agent-123 (5 μM; 2 h) inhibits NF-κB protein expression in LPS-stimulated RAW264.7 cells at 5 μM^[1].

Innate Immunity

Cytokines and Chemokines

Anti-inflammatory agent-123 (10 μM) inhibits the production of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 in LPS-induced RAW264.7 cells^[1].

Others

Anti-inflammatory agent-123 (50 μM; 24 h) does not exhibit significant cytotoxicity in RAW264.7 cells at 50 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

RAW264.7 mouse mononuclear macrophage cells
Concentration:

50 μM
Incubation Time:

24 h
Result:

Showed no significant cytotoxicity at 50 μM, with cell viability exceeding 80%.

Western Blot Analysis^[1]

Cell Line:

RAW264.7 mouse mononuclear macrophage cells
Concentration:

5 μM
Incubation Time:

2 h (pre-incubation); 6 h (LPS treatment)
Result:

Suppressed the activation of NF-κB in LPS-induced RAW264.7 cells.

Related Protocols :

Chemical Information

Molecular Weight 336.39
Formula C₂₃H₁₆N₂O
SMILES

CC1=CC=C(N=C(C(C2=CC=CC=C2)=O)C3=C4NC5=C3C=CC=C5)C4=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xie C, et al. A Cascade Annulation for the Synthesis of 11H-Indolo[3,2-c]quinolines and In Vitro Anti-Inflammatory Assays. The Journal of organic chemistry. 2026 Sep 04;91(35):11978-11991.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Anti-inflammatory agent-123

All NF-κB Isoforms

All TNF Receptor Isoforms

All Interleukin Related Isoforms

All NO Synthase Isoforms