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Cat. No.: HY-187913

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Anti-TB agent 2

Anti-TB agent 2 is an anti-tuberculosis agent. Anti-TB agent 2 exhibits antibacterial activity against Mycobacterium tuberculosis. Anti-TB agent 2 shows bactericidal activity in an acute tuberculosis mouse model. Anti-TB agent 2 can be used for tuberculosis research.

For research use only. We do not sell to patients.

CAS No.: 2252473-48-4
Formula: C₂₁H₂₄F₃N₃O₃S
Molecular Weight:455.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anti-TB agent 2 Chemical Structure

CAS No.: 2252473-48-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Vero	IC50	64 μg/mL	Cytotoxicity against Vero cells assessed as IC50 >64 μg/mL after 48 hrs incubation by MTT assay. Cytotoxicity against Vero cells assessed as IC50 >64 μg/mL after 48 hrs incubation by MTT assay.	34126456

In Vitro

Bacterial InfectionOthers

Bacterial Infection

Anti-TB agent 2 (Compound 6b) (16-24 h) inhibits Mycobacterium tuberculosis H37Rv with an MIC <0.016 μg/mL^[1].

Others

Anti-TB agent 2 (0.26-64 μg/mL; 48 h) exhibited an IC₅₀ >64 μg/mL against Vero cells^[1].
Anti-TB agent 2 (30 min) is stable in mouse hepatocytes, with 80.6% remaining after 30 min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

Vero cells
Concentration:

64 to 0.26 μg/mL
Incubation Time:

48 h; 4 h (MTT)
Result:

Had IC₅₀ >64 μg/mL against Vero cells.

In Vivo

Bacterial Infection

Anti-TB agent 2 exhibits bactericidal activity in an acute tuberculosis mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 2252473-48-4
Molecular Weight 455.49
Formula C₂₁H₂₄F₃N₃O₃S
SMILES

O=C1C=C(N2CCN(CC3CCCCC3)CC2)SC4=C1C=C(C(F)(F)F)C=C4[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li P, et al. Identification of novel benzothiopyranones with ester and amide motifs derived from active metabolite as promising leads against Mycobacterium tuberculosis. European journal of medicinal chemistry. 2021 Oct 15;222:113603. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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