Anti-uPAR Antibody
Anti-uPAR Antibody (FL1; FL1-PNU antibody) is a monoclonal antibody targeting uPAR that binds uPAR and promotes lysosomal payload delivery through aggregation-mediated endocytosis. Anti-uPAR Antibody can be used in ADC synthesis-related research, such as serving as the carrier antibody for FL1-PNU.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Species Reactivity
Human; Mouse
In Vitro
Anti-uPAR Antibody ‑derived fluorescent tracer A647‑FL1 undergoes robust uPAR‑dependent cellular and lysosomal internalization in uPAR‑positive U937 and KPC cells, and this uptake process does not rely on LRP1 as evidenced by the observation that the LRP1 antagonist RAP cannot abolish internalization[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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SMILES
[Anti-uPAR Antibody]
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Synonyms
FL1; FL1-PNU antibody
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-uPAR Antibody Related Classifications
HY-P992526 Related Classifications
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Keywords
- Anti-uPAR Antibody
- FL1
- FL1-PNU antibody
- FL 1
- FL-1
- ADC Antibodies
- Transmembrane Glycoprotein
- DNA damage
- PARP-dependent apoptosis
- PDAC xenograft
- S-phase arrest
- bystander cytotoxicity
- clustering-mediated endocytosis
- lysosomal payload delivery
- pancreatic ductal adenocarcinoma
- tumor microenvironment
- uPAR
- Inhibitor
- inhibitor
- inhibit