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Cat. No.: HY-185699

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Antibacterial agent 350

Antibacterial agent 350 is a membrane stabilizer/disruptor with antibacterial activity. Antibacterial agent 350 reduces glucose-induced efflux efficiency and slightly impairs outer membrane stability. Antibacterial agent 350 significantly decreases the bacteriostatic MIC₅₀ of Ceftazidime (HY-B0593) or Ciprofloxacin (HY-B0356), but increases the MIC₅₀ of Amikacin (HY-B0509A). Antibacterial agent 350 can be used for the research of Pseudomonas aeruginosa infections.

For research use only. We do not sell to patients.

CAS No.: 1394833-44-3
Formula: C₂₅H₅₀N₄
Molecular Weight:406.69

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antibacterial agent 350 Chemical Structure

CAS No.: 1394833-44-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Bacterial Infection

Antibacterial agent 350 (compound 3) (15.6-125 μM; 60 min) causes slight outer membrane permeabilization in Pseudomonas aeruginosa PA01, but its primary activity is potent efflux inhibition, which is significantly greater than its permeabilization effect at all tested concentrations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

CHO-K1 Chinese Hamster Ovary cells
Concentration:

30-1200 μM
Incubation Time:

24 h
Result:

Had an IC₅₀ of 320.5 μM for CHO-K1 cells, which is significantly higher than the IC₅₀ of positive control doxorubicin (48.3 μM).

Related Protocols :

Chemical Information

CAS No. 1394833-44-3
Molecular Weight 406.69
Formula C₂₅H₅₀N₄
SMILES

NCCCNCCCCNCCCNC/C=C(CC/C=C(CC/C=C(C)/C)\C)\C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Borselli D, et al. Polyamino-isoprenic derivatives block intrinsic resistance of P. aeruginosa to doxycycline and chloramphenicol in vitro[J]. PLoS One, 2016, 11(5): e0154490.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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