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Cat. No.: HY-189124

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Antibacterial agent 372

Antibacterial agent 372 is a potent antibacterial agent. Antibacterial agent 372 is a DNA gyrase inhibitor that binds to the ATP-binding pocket of the GyrB subunit, downregulates gyrB gene expression, and impedes DNA replication and supercoiling. Antibacterial agent 372 exhibits broad-spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Antibacterial agent 372 can be used for research on microbial infections.

For research use only. We do not sell to patients.

Formula: C₁₄H₁₁N₃O₄
Molecular Weight:285.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antibacterial agent 372 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

DNA Gyrase

All Topoisomerase Isoforms :

In Vitro

Bacterial InfectionOthers

Bacterial Infection

Antibacterial agent 372 (compound 4) exhibits potent broad-spectrum antibacterial activity, especially against Staphylococcus aureus, with an MIC of 3.12 µg/mL^[1].
Antibacterial agent 372 (0.25-0.8× MIC; 2-4 h) disrupts and eradicates biofilms and inhibits respiratory chain dehydrogenase activity in P. aeruginosa biofilms in a concentration- and time-dependent manner^[1].
Antibacterial agent 372 (0.5× MIC) downregulates DNA gyrase gene (gyrB) expression in E. coli cells^[1].

Others

Antibacterial agent 372 (5-100 μg/mL; 24-48 h) exhibits low cytotoxicity against HepG2 cells and maintains high cell viability even at a concentration of 100 µg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HepG2
Concentration:

5, 100 μg/mL
Incubation Time:

24, 48 h
Result:

Exhibited low cytotoxicity.
Maintained 88% cell viability at the dose of 100 μg/mL, and 99% at the dose of 5 μg/mL.

Related Protocols :

Chemical Information

Molecular Weight 285.25
Formula C₁₄H₁₁N₃O₄
SMILES

O=CN(C(C1=CC=CO1)C2)N=C2C3=CC=C([N+]([O-])=O)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hassan AMA, et al. Synthesis and molecular docking of novel pyrazole, pyrimidine, and pyridine derivatives as potent antimicrobial, antibiofilm, and anticancer agents. Scientific reports. 2026 Aug 08;16(1):24543.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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