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Cat. No.: HY-189410

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Anticancer agent-363

Anticancer agent-363 is an anticancer agent that exhibits cytotoxic activity against cancer cells and is selective for non-cancerous fibroblasts. Anticancer agent-363 has the highest binding affinity for c-Met protein. Anticancer agent-363 can be used for research on lung cancer and mammary adenocarcinoma.

For research use only. We do not sell to patients.

Formula: C₂₀H₁₆BrClN₆O₄S
Molecular Weight:551.80

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent-363 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
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References
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC50	0.29 μM	Cytotoxicity against human A549 non-small cell lung carcinoma cells assessed as reduction in cell viability by MTT assay. Cytotoxicity against human A549 non-small cell lung carcinoma cells assessed as reduction in cell viability by MTT assay.	42643104
MCF7	IC50	3.1 μM	Cytotoxicity against human MCF-7 breast adenocarcinoma cells assessed as reduction in cell viability by MTT assay. Cytotoxicity against human MCF-7 breast adenocarcinoma cells assessed as reduction in cell viability by MTT assay.	42643104
NIH3T3	IC50	66.36 μM	Cytotoxicity against normal noncancerous mouse embryonic fibroblast NIH/3T3 cells assessed as reduction in cell viability by MTT assay. Cytotoxicity against normal noncancerous mouse embryonic fibroblast NIH/3T3 cells assessed as reduction in cell viability by MTT assay.	42643104

In Vitro

Anti-cancer

Anticancer agent-363 (Compound 10d) exhibits the most potent anticancer activity against A549 (IC₅₀ = 0.29 μM) and MCF-7 (IC₅₀ = 3.1 μM) cell lines, and shows significantly lower toxicity toward normal NIH/3T3 fibroblasts (IC₅₀ = 66.36 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Molecular Weight 551.80
Formula C₂₀H₁₆BrClN₆O₄S
SMILES

COC1=CC=C(NC(CSC2=NN=C(C3=CC(Br)=NN3C4=C(Cl)C=CC=N4)O2)=O)C(OC)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dave PA, et al. Potential c-Met-targeted pyrazole-pyridine-oxadiazole hybrids: synthesis, anticancer activity, and computational rationale. Organic & biomolecular chemistry. 2026 Sep 16;24(35):7351-7366.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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