Antifungal agent 179
Antifungal agent 179 is an indole-oxazole alkaloid analog with broad-spectrum antifungal activity against plant pathogenic fungi. Antifungal agent 179 disrupts the integrity of fungal hyphal cell membranes, increases membrane permeability, and causes leakage of intracellular electrolytes and cytoplasm. Antifungal agent 179 exhibits protective and curative activity in a tomato in vivo model infected with Botrytis cinerea, with low toxicity to mung bean plants. Antifungal agent 179 can be used for research on crop fungal infections.
For research use only. We do not sell to patients.
- CAS No.: 3105221-19-7
- Formula: C14H14N2O
- Molecular Weight:226.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Antifungal agent 179 (EC50 100 mg/L; 20-240 min) disrupts the cell membrane of Sclerotinia sclerotiorum, causing cytoplasmic leakage[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Antifungal agent 179 (100-200 mg/L; spraying; 48 h) exhibits low toxicity to mung bean plants, with a germination rate of 100% at both 100 and 200 mg/L concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Tomato fruits[1]
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Dosage:100, 200 mg/L (protective)
100, 200 mg/L (curative) -
Administration:sprayed; placed into an illumination incubator for 4 days.
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Result:Exhibited a protective activity of 57.7% at 100 mg/L.
Exhibited a curative activity of 38.0% at 100 mg/L.
Exhibited a protective activity of 73.2% at 200 mg/L.
Exhibited a curative activity of 69.6% at 200 mg/L.
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Animal Model:Mung bean seeds[1]
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Dosage:100 mg/L; 200 mg/L
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Administration:applied; 48 h
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Result:Reached a germination rate of 100% at 100 mg/L.
Reached a germination rate of 100% at 200 mg/L.
Chemical Information
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CAS No. 3105221-19-7
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Molecular Weight 226.27
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Formula C14H14N2O
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SMILES
CCCN1C=C(C2=CN=CO2)C3=C1C=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antifungal agent 179 Related Classifications
HY-189259 Related Classifications
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Keywords
- Antifungal agent 179
- 3105221-19-7
- Antifungal agent179
- Antifungal agent-179
- Fungal
- Botrytis cinerea Pers.
- cytoplasmic leakage
- plant pathogenic fungi
- tomatoes
- mung bean seed germination
- Sclerotinia sclerotiorum
- Rhizoctonia solani
- hyphal cell membrane integrity
- Pyricularia oryzae
- Colletotrichum capsici
- Inhibitor
- inhibitor
- inhibit