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Cat. No.: HY-189426

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Antifungal agent 182

Antifungal agent 182 is a mitochondrial complex III (Qo site) inhibitor with an IC₅₀ of 7.05 mg/L. Antifungal agent 182 binds to the Qo pocket, blocking electron transfer and impairing ATP synthesis. Antifungal agent 182 exhibits inhibitory activity against R. solani and P. capsici. Antifungal agent 182 can be used for research on rice sheath blight and Phytophthora capsici infection in pepper.

For research use only. We do not sell to patients.

CAS No.: 3134776-29-4
Formula: C₁₇H₁₂O₃S
Molecular Weight:296.34

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Please store the product under the recommended conditions in the Certificate of Analysis.

Antifungal agent 182 Chemical Structure

CAS No.: 3134776-29-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Fungal Infection

Antifungal agent 182 (A21) exhibits potent broad-spectrum antifungal activity, especially against P. capsici (EC₅₀ = 0.59 mg/L) and R. solani (EC₅₀ = 0.69 mg/L)^[1].
Antifungal agent 182 causes visible morphological disruption to R. solani and P. capsici mycelia at their respective EC₅₀ concentrations^[1].
Antifungal agent 182 causes severe toxicological damage to the cellular structures of R. solani and P. capsici, including mitochondrial degradation and vacuolar enlargement^[1].
Antifungal agent 182 disrupts membrane integrity in P. capsici, leading to increased permeability and leakage of charged substances^[1].
Antifungal agent 182 acts as an inhibitor of mitochondrial complex III (IC₅₀ = 7.05 mg/L) in P. capsici^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Infectious Diseases

Chemical Information

CAS No. 3134776-29-4
Molecular Weight 296.34
Formula C₁₇H₁₂O₃S
SMILES

O=C1OC(C2=CC=CS2)C(C3=CC4=CC=CC=C4O3)C1=C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yang D, et al. Design, Synthesis, and Fungicidal Activity of Novel α-Methylene-γ-Butyrolactone Derivatives Bearing Benzofuran-2-yl Moiety. Journal of agricultural and food chemistry. 2026 Aug 26;74(33):26017-26030.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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