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Cat. No.: HY-189798

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Antifungal agent 186

Antifungal agent 186 is an antifungal agent targeting CYP51. Antifungal agent 186 coordinates with the heme iron of CYP51 through the triazole ring nitrogen atom, inhibiting sterol 14α-demethylase and thereby disrupting ergosterol biosynthesis. Antifungal agent 186 disrupts hyphal morphology and interferes with membrane-associated processes. Antifungal agent 186 exhibits broad-spectrum antifungal activity against various plant pathogenic fungi and oomycetes, and shows protective and curative efficacy on apple fruit, tomato fruit, and Suzhou green leaves. Antifungal agent 186 can be used in research related to fungal infections (such as gray mold).

For research use only. We do not sell to patients.

Formula: C₁₅H₁₇F₄N₃OS
Molecular Weight:363.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antifungal agent 186 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

All Cytochrome P450 Isoforms :

In Vitro

Fungal InfectionLipid Metabolism

Fungal Infection

Antifungal agent 186 (Compound 7n) (0.001-20.0 μg/mL) exhibits potent broad-spectrum activity against Botrytis cinerea, Phytophthora capsici, Curvularia lunata, and Alternaria solani, with EC₅₀ values of 0.007, 0.121, 0.122, and 0.068 μg/mL, respectively^[1].
Antifungal agent 186 (0.010 μg/mL; 4 days) disrupts the mycelial morphology of Botrytis cinerea, causing surface shrinkage and distortion^[1].
Antifungal agent 186 (50-200 μg/mL; 2-7 days) exhibits both protective and curative efficacy against plant pathogenic fungal infections and shows protective and curative activity on plant tissues, with a protective efficacy of 94.6% against Valsa mali on apple fruit at high concentrations and a protective efficacy of 100% against Sclerotinia sclerotiorum on Suzhou green leaves at medium concentrations^[1].

Fungal Infection

Lipid Metabolism

Antifungal agent 186 (4 days) induces 2702 DEGs in Botrytis cinerea and affects membrane-related and sterol biosynthesis pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 363.37
Formula C₁₅H₁₇F₄N₃OS
SMILES

OC(CN1N=CN=C1)(C2=CC=C(F)C=C2F)C(F)(F)SCC(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bai H, et al. Design, Synthesis and Fungicidal Activity of New 1,2,4-Triazole Derivatives Containing Oxime Ether and Phenoxyl Pyridinyl Moiety. Molecules. 2020 Dec 11;25(24):5852.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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