Antimicrobial agent-55
Antimicrobial agent-55 is a ciprofloxacin-derived multi-target antibacterial agent (Antibacterial) that inhibits E. coli DNA gyrase, S. aureus topoisomerase IV and LpxC with IC50 values of 0.315, 1.553 and 0.108 μM, respectively. The MIC of Antimicrobial agent-55 against E. coli ATCC 8739 is 0.27 μM. Antimicrobial agent-55 induces bacterial DNA damage and abnormal cell division. Antimicrobial agent-55 is applicable to studies on multi-target antibacterial mechanisms, infections caused by Gram-positive and Gram-negative bacteria, and bacterial drug resistance.
For research use only. We do not sell to patients.
- Formula: C27H25FN6O4S
- Molecular Weight:548.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
DNA gyrase 0.315 μM (IC50, E. coli) |
topoisomerase IV 1.553 μM (IC50, S. aureus ) |
LpxC 0.108 μM (IC50) |
In Vitro
Antimicrobial agent-55 induces topoisomerase-inhibiting phenotypes in *Bacillus subtilis* 2020, including cell elongation, nucleoid condensation, abnormal FtsZ ring localization, and membrane foci[1].
Antimicrobial agent-55 activates the SOS DNA damage response in Bacillus subtilis UG10, which is evidenced by the formation of RecA aggregates[1].
Antimicrobial agent-55 inhibits E. coli DNA gyrase, S. aureus topoisomerase IV, and LpxC, with IC50 values of 0.315, 1.553, and 0.108 μM, respectively[1].
Antimicrobial agent-55 (20 days) exhibits extremely low potential for the development of bacterial resistance in Staphylococcus aureus, with only a slight 2- to 3-fold increase in MIC observed within 20 days[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 548.59
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Formula C27H25FN6O4S
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SMILES
O=C1C(C(NCC2=NN=C(S)O2)=O)=CN(C3CC3)C4=C1C=C(F)C(N5CCN(C(C6=CC=CC=C6)=O)CC5)=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antimicrobial agent-55 Related Classifications
HY-187202 Related Classifications
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