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Cat. No.: HY-189699

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Antiparasitic agent-50

Antiparasitic agent-50 is a parasite inhibitor. Antiparasitic agent-50 inhibits the proliferation of intracellular Toxoplasma gondii tachyzoites and Trypanosoma cruzi amastigotes. Antiparasitic agent-50 shows no significant cytotoxicity to human fibroblasts. Antiparasitic agent-50 can be used in research related to toxoplasmosis and Chagas disease.

For research use only. We do not sell to patients.

Formula: C₃₃H₄₀N₄O₆
Molecular Weight:588.69

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antiparasitic agent-50 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HFF	CC₅₀	200 μM	Cytotoxicity against human foreskin fibroblasts (HFFs) with CC₅₀ >200 μM after 72 hrs exposure measured by MTT assay. Cytotoxicity against human foreskin fibroblasts (HFFs) with CC₅₀ >200 μM after 72 hrs exposure measured by MTT assay.	42748749

In Vitro

Parasitic InfectionOthers

Parasitic Infection

Antiparasitic agent-50 (Compound16) (0.19-12 μM; 72 h) inhibits intracellular T. gondii RH-2F1 tachyzoites in HFFs with an EC₅₀ of 0.61 μM and a selectivity index >327.87^[1].
Antiparasitic agent-50 (48 h) inhibits intracellular T. cruzi Tulahuen lacZ amastigotes in LLC-MK2 cells with an EC₅₀ of 81.88 μM and a selectivity index >2.44^[1].

Others

Antiparasitic agent-50 (3.12-200 μM; 72 h) displays a CC₅₀ >200 μM in HFFs, indicating that no cytotoxicity was detected at concentrations up to 200 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Molecular Weight 588.69
Formula C₃₃H₄₀N₄O₆
SMILES

O=C(OC)CCC1=CNC2=C1C3=CC=C(OC)C=C3N=C2C4=CC=C(NC([C@@H](NC(OC(C)(C)C)=O)C(C)(C)C)=O)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Torres T, et al. C-1 functionalization of the marinoquinoline scaffold generates novel and selective inhibitors of Toxoplasma gondii and Trypanosoma cruzi. Bioorganic chemistry. 2026 Sep 10;182:110509.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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