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Cat. No.: HY-189940

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Antitubercular agent-61

Antitubercular agent-61 is an antitubercular agent. Antitubercular agent-61 exhibits bactericidal activity against Mycobacterium tuberculosis. Antitubercular agent-61 is more selective for Mycobacterium species than for ESKAPE pathogens.

For research use only. We do not sell to patients.

Formula: C₂₄H₂₂N₆OS
Molecular Weight:442.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antitubercular agent-61 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Vero	CC₅₀	10.5 μg/mL	Cytotoxicity against African green monkey Vero cells assessed as 50% reduction in viability by MTT assay. Cytotoxicity against African green monkey Vero cells assessed as 50% reduction in viability by MTT assay.	42760852

In Vitro

Bacterial Infection

Antitubercular agent-61 (Compound 8K) (10 days) is a potent in vitro antimycobacterial agent with an MIC of 0.25 μg/mL against Mycobacterium tuberculosis and remains active against Ethambutol (HY-B0535)-resistant isolates^[1].
Antitubercular agent-61 has a CC₅₀ of 10.5 μg/mL in Vero cells, with a selectivity index of 42 against Mycobacterium tuberculosis H37Rv^[1].
Antitubercular agent-61 exerts a bactericidal effect on Mycobacterium tuberculosis, resulting in a time-dependent decrease in viable bacterial counts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Bacterial live/dead nucleic-acid viability staining

Chemical Information

Molecular Weight 442.54
Formula C₂₄H₂₂N₆OS
SMILES

O=C(N/N=C/C1=CC=C(N2CCN(C3=NSC4=CC=CC=C34)CC2)C=C1)C5=CC=NC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sharma V, et al. Design, Synthesis, Antimycobacterial Evaluation, and In Silico Investigation of Benzisothiazole-Based Hydrazide Derivatives as Potential Anti-Tuberculosis Agents. Chemical biology & drug design. 2026 Sep;108(3):e70405.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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