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Cat. No.: HY-184757

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Antitumor agent-224

Antitumor agent-224 is an antitumor agent associated with LD₅₀ toxicity in rats. Antitumor agent-224 exerts alkylating activity via the formation of aziridine intermediates, thereby interacting with biological macromolecules. Antitumor agent-224 exhibits activity against cancer cells and leukemia cells. Antitumor agent-224 can be used in the research of cancers such as leukemia.

For research use only. We do not sell to patients.

CAS No.: 1141-37-3
Formula: C₁₁H₁₃Cl₂NO₂
Molecular Weight:262.13

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antitumor agent-224 Chemical Structure

CAS No.: 1141-37-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vivo
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	50 μM Compound: 4	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 30243153]
Bel-7402	IC₅₀	200 μM Compound: 15	Antiproliferative activity against human Bel7402 cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human Bel7402 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 25050168]
Bel-7402	IC₅₀	46.45 μM Compound: 4	Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay	[PMID: 29524728]
Bel-7402	IC₅₀	23.94 μM Compound: 16	Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay	[PMID: 29407983]
Bel-7402	IC₅₀	23.94 μM Compound: 4	Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay	[PMID: 30243153]
Bel7402/5-FU	IC₅₀	80 μM Compound: 4	Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by MTT assay Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by MTT assay	[PMID: 29524728]
Bel7402/5-FU	IC₅₀	100 μM Compound: 16	Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by MTT assay Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by MTT assay	[PMID: 29407983]
HepG2	IC₅₀	100 μM Compound: 9	Antiproliferative activity against human HepG2 cells treated for 24 hrs measured after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells treated for 24 hrs measured after 72 hrs by MTT assay	[PMID: 29037951]
HL-60	IC₅₀	12.29 μM Compound: 9	Antiproliferative activity against human HL60 cells treated for 24 hrs measured after 72 hrs by MTT assay Antiproliferative activity against human HL60 cells treated for 24 hrs measured after 72 hrs by MTT assay	[PMID: 29037951]
HL-60	IC₅₀	12.36 μM Compound: 4	Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay	[PMID: 29524728]
HL-60	IC₅₀	6.02 μM Compound: 16	Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay	[PMID: 29407983]
K562	IC₅₀	142.67 μM Compound: 15	Antiproliferative activity against human K562 cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 25050168]
L02	IC₅₀	100 μM Compound: 15	Cytotoxicity against human L02 cells by MTT assay Cytotoxicity against human L02 cells by MTT assay	[PMID: 25050168]
L02	IC₅₀	68.57 μM Compound: 4	Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay	[PMID: 29524728]
L02	IC₅₀	32.86 μM Compound: 16	Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay	[PMID: 29407983]
L02	IC₅₀	32.86 μM Compound: 4	Cytotoxicity against human LO2 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human LO2 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 30243153]
L1210	IC₅₀	17039 ng/mL Compound: 4f	The activity in vitro on L1210 murine leukemia cells, activity expressed as IC50 The activity in vitro on L1210 murine leukemia cells, activity expressed as IC50	10.1016/S0960-894X(01)80515-1
LoVo	IC₅₀	100 μM Compound: 2a	Inhibitory concentration was evaluated against colorectal tumar cell line LoVo Inhibitory concentration was evaluated against colorectal tumar cell line LoVo	[PMID: 8676345]
MCF-10A	IC₅₀	40 μM Compound: 11	Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay	[PMID: 34365102]
MCF7	IC₅₀	152.15 μM Compound: 15	Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 25050168]
MCF7	IC₅₀	50 μM Compound: 4	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 30243153]
MCF7	IC₅₀	20 μM Compound: 11	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay	[PMID: 34365102]
MDA-MB-231	IC₅₀	20 μM Compound: 11	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay	[PMID: 34365102]
MGC-803	IC₅₀	146.2 μM Compound: 15	Antiproliferative activity against human MGC803 cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human MGC803 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 25050168]
PBMC	IC₅₀	200 μM Compound: 9	Antiproliferative activity against human PBMC treated for 24 hrs measured after 72 hrs by MTT assay Antiproliferative activity against human PBMC treated for 24 hrs measured after 72 hrs by MTT assay	[PMID: 29037951]
PC-3	IC₅₀	63.46 μM Compound: 9	Antiproliferative activity against human PC3 cells treated for 24 hrs measured after 72 hrs by MTT assay Antiproliferative activity against human PC3 cells treated for 24 hrs measured after 72 hrs by MTT assay	[PMID: 29037951]
PC-3	IC₅₀	57.27 μM Compound: 4	Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay	[PMID: 29524728]
PC-3	IC₅₀	80 μM Compound: 16	Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay	[PMID: 29407983]
THP-1	IC₅₀	8.56 μM Compound: 9	Antiproliferative activity against human THP1 cells treated for 24 hrs measured after 72 hrs by MTT assay Antiproliferative activity against human THP1 cells treated for 24 hrs measured after 72 hrs by MTT assay	[PMID: 29037951]
U-251	IC₅₀	50 μM Compound: 2	Antiproliferative activity against human U-251 assessed as cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human U-251 assessed as cell viability incubated for 48 hrs by MTT assay	[PMID: 39832391]
U-87MG ATCC	IC₅₀	50 μM Compound: 2	Antiproliferative activity against human U-87 MG assessed as cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human U-87 MG assessed as cell viability incubated for 48 hrs by MTT assay	[PMID: 39832391]

In Vivo

Anti-cancer

Antitumor agent-224 (compound 5) exhibits activity against Walker 256 rat carcinoma with an observed log 1/CED₉₀ of 3.81, and has an observed log 1/CLD₉₀ of 3.58^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Acute Systemic Toxicity Study

Chemical Information

CAS No. 1141-37-3
Molecular Weight 262.13
Formula C₁₁H₁₃Cl₂NO₂
SMILES

O=C(C1=CC=C(N(CCCl)CCCl)C=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Panthananickal A, et al. Structure-activity relationships in antitumor aniline mustards. J Med Chem. 1978 Jan;21(1):16-26. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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