Antitumor agent-80
Antitumor agent-80 (compound 11) is an orally active and potent antitumor agent. Antitumor agent-80 induces apoptosis in tumor cells.
For research use only. We do not sell to patients.
- CAS No.: 2758520-84-0
- Formula: C24H20ClNO2
- Molecular Weight:389.87
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
Antitumor agent-80 (compound 11) (5 μM, 48 h) induces apoptosis and increase in PARP cleavage in tumor cells[1].
Antitumor agent-80 (0-10 μM, 96 h) shows cell growth inhibitory activity against breast and hepatocellular carcinoma cell lines[1].
Growth Inhibitory Activity of Antitumor agent-80 against Hepatocellular Carcinoma and Breast Cancer Cell Line Panel[1].
| hepatocellular carcinoma | IC50 (μM) | breast | IC50 (μM) |
| Huh7 | 1.3 | MCF7 | 3.8 |
| HepG2 | 2.1 | MDA-MB231 | 2.0 |
| SNU475 | 1.7 | MDA-MB468 | 2.8 |
| Hep3B | 3.0 | SKBR3 | 3.5 |
| FOCUS | 2.1 | ZR75 | 7.6 |
| Hep40 | 8.6 | MCF10A | 12.1 |
| PLC-PRF-5 | 9.5 | ||
| Mahlavu | 3.2 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Huh7, Mahlavu, MDA-MB-231, and MCF-7 cells
-
Concentration:5 μM
-
Incubation Time:48 h
-
Result:Caused the increase in PARP cleavage in both breast cancer cells (MCF7 and MDA-MB-231) and hepatocellular carcinoma cells (Mahlavu).
-
Cell Line:Huh7, Mahlavu, MDA-MB-231, and MCF-7 cells
-
Concentration:10 μM, 5 μM, 2.5 μM
-
Incubation Time:96 h
-
Result:Caused inhibition in the growth of both breast and hepatocellular carcinoma cell lines.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Athymic nude mice (6-8 weeks old, with Mahlavu cells or MDA-MB-231 cells)[1]
-
Dosage:40 mg/kg
-
Administration:Orally, twice a week, for 4 weeks
-
Result:In the Mahlavu xenografts, had a significant reduction (85%) in tumor volume. For MDA-MB-231 xenografts, resulted in about a 50% decrease in tumor volumes as compared to the control group.
Chemical Information
-
CAS No. 2758520-84-0
-
Molecular Weight 389.87
-
Formula C24H20ClNO2
-
SMILES
CC1=CC=CC=C1COC2=CC=C(C3=NOC(C)=C3C4=CC=C(Cl)C=C4)C=C2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-80 Related Classifications
HY-151620 Related Classifications
Powered by Bioz