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Cat. No.: HY-165465

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Apo6619

Apo6619 is an iron chelator with antibacterial activity that inhibits a variety of common bacteria associated with hospital-acquired infections. Apo6619 inhibits the growth of relevant bacterial strains in cation-adjusted Mueller-Hinton broth and RPMI 1640 tissue culture medium. Apo6619 can be used in antibacterial research on hospital-acquired infection-related bacteria based on the iron chelation mechanism.

For research use only. We do not sell to patients.

CAS No.: 887774-94-9
Formula: C₁₁H₁₄N₂O₃
Molecular Weight:222.24

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Apo6619 Chemical Structure

CAS No.: 887774-94-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Bacterial Infection

Apo6619 inhibits the growth of A. baumannii ATCC 17978 and 19606 in CAMHB, with an MIC of 256 μg/mL for both strains; it also exhibits an MIC of 256 μg/mL against E. coli ATCC 35718 and 43888^[1].
Apo6619 exhibits MIC values of > 512 μg/mL against Staphylococcus aureus ATCC 25923, 43300, Pseudomonas aeruginosa PAO1, ATCC 27853, and Klebsiella pneumoniae BAA-2146, 700603 in CAMHB^[1].
Apo6619 inhibits the growth of A. baumannii ATCC 17978 and 19606 in RPMI 1640 medium, with MIC values of 64 μg/mL and 128 μg/mL, respectively; it exhibits an MIC of 256 μg/mL against both E. coli ATCC 35718 and 43888^[1].
The MIC of Apo6619 against P. aeruginosa PAO1, K. pneumoniae BAA-2146 and 700603 in RPMI 1640 medium is 512 μg/mL, while its MIC against P. aeruginosa ATCC 27853 is > 512 μg/mL^[1].
Apo6619 exhibits antibacterial activity in the time-kill assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 887774-94-9
Molecular Weight 222.24
Formula C₁₁H₁₄N₂O₃
SMILES

O=C1C=C(N(C(C(=O)NC)=C1O)C2CC2)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Thompson MG, et al. Antibacterial activities of iron chelators against common nosocomial pathogens. Antimicrobial agents and chemotherapy. 2012 Oct;56(10):5419-21.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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