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Cat. No.: HY-202191

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ARC39

Name: ARC39
Brand: MedChemExpress
SKU: HY-202191
Price: 350.00 USD
Availability: PreOrder

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

ARC39 is an acid sphingomyelinase (ASM) inhibitor.

For research use only. We do not sell to patients.

Purity : 98.5%
CAS No.: 15049-89-5
Formula: C₈H₂₁NO₆P₂
Molecular Weight:289.20

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

ARC39 Chemical Structure

CAS No.: 15049-89-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

ARC39 is an acid sphingomyelinase (ASM) inhibitor^[1].

All Phospholipase Isoforms :

In Vitro

ARC39 (30 min) potently inhibits recombinant human acid sphingomyelinase with an IC₅₀ of 20 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 15049-89-5
Appearance Solid
Molecular Weight 289.20
Formula C₈H₂₁NO₆P₂
SMILES

O=P(O)(O)C(N)(CCCCCCC)P(=O)(O)O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Int Arch Allergy Immunol

Acid Sphingomyelinase-Ceramide Axis Modulation Is Associated with Thymic Stromal Lymphopoietin Release and Epithelial Barrier Dysfunction in an in vitro Type 2 Inflammation Model Relevant to Pediatric Rhinitis. [Abstract]

2026 Aug 3:1. PMID: 42545914

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang K, et al. Discovery of Potent, Selective, and Direct Acid Sphingomyelinase Inhibitors with Antidepressant Activity. J Med Chem. 2020;63(3):961-974. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References

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ARC39

Publications Citing Use of MedChemExpress (MCE) ARC39

All Phospholipase Isoforms