ARL 17477 (Standard)
ARL 17477 (Standard) is the analytical standard of ARL 17477 (HY-107720). This product is intended for research and analytical applications. ARL 17477 is a blood-brain barrier-penetrant selective neuronal nitric oxide synthase (nNOS) inhibitor with an IC50 of 1 μM. ARL 17477 reduces nitric oxide production and activates TFEB and lysosomal biogenesis, induces lysosomal membrane permeabilization, but inhibits autophagy-lysosomal function, autophagic flux, protein aggregate clearance, and proliferation. ARL 17477 induces ERK hyperphosphorylation and slight AKT inhibition. ARL 17477 exhibits NOS1 -independent anticancer activity against multiple cancer cells. ARL 17477 inhibits xenograft tumor growth in vivo. ARL 17477 can be used in research on colon cancer, non-small cell lung cancer, osteosarcoma, pancreatic cancer, arterial occlusion, and pain.
For research use only. We do not sell to patients.
- CAS No.: 866914-87-6
- Formula: C20H22Cl3N3S
- Molecular Weight:442.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 866914-87-6
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Molecular Weight 442.83
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Formula C20H22Cl3N3S
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SMILES
[H]Cl.[H]Cl.N=C(C1=CC=CS1)NC2=CC=C(CCNCC3=CC(Cl)=CC=C3)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. Nomura TK, et al. ARL-17477 is a dual inhibitor of NOS1 and the autophagic-lysosomal system that prevents tumor growth in vitro and in vivo. Scientific reports. 2023 Jul 04;13(1):10757. [Content Brief]
[4]. Oberkrom K, et al. Targeting GPR183 to reduce peripheral sensitization: evidence from rodent and human tissue analyses. bioRxiv. 2026 Jan 16:2026-01. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ARL 17477 (Standard) Related Classifications
HY-107720R Related Classifications
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Keywords
- ARL 17477 (Standard)
- 866914-87-6
- Reference Standards
- NO Synthase
- Autophagy
- PERK
- ERK hyperphosphorylation
- TFEB
- autophagic flux
- autophagy-lysosomal function
- blood-brain barrier
- endothelial nitric oxide synthase
- lysosomal biogenesis
- lysosomal membrane permeabilization
- neuronal nitric oxide synthase
- nitric oxide
- Inhibitor
- inhibitor
- inhibit