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Cat. No.: HY-12924

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ATR-IN-1

ATR-IN-1 is a selective ATR inhibitor with an IC₅₀ of 0.5 nM. ATR-IN-1 shows no hERG inhibitory effect. ATR-IN-1 inhibits the growth of ATM-deficient melanoma.

For research use only. We do not sell to patients.

CAS No.: 1639974-69-8
Formula: C₁₈H₁₉N₇O
Molecular Weight:349.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ATR-IN-1 Chemical Structure

CAS No.: 1639974-69-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

ATR-IN-1 is a selective ATR inhibitor with an IC₅₀ of 0.5 nM. ATR-IN-1 shows no hERG inhibitory effect. ATR-IN-1 inhibits the growth of ATM-deficient melanoma^[1].

IC₅₀ & Target

^[1]

ATR

0.5 nM (IC₅₀)

All ATM/ATR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HT-144	GI50	0.35 μM	Inhibition of growth of ATM-null human HT144 melanoma cells after 72 hrs continuous exposure measured by CellTiter-Glo assay. Inhibition of growth of ATM-null human HT144 melanoma cells after 72 hrs continuous exposure measured by CellTiter-Glo assay.	25589928

In Vitro

OthersAnti-cancer

Others

ATR-IN-1 (Compound 13) inhibits ATR with an IC₅₀ of 0.0005 µM and shows selectivity over ATM (IC₅₀ 15 µM) and DNAPK (IC₅₀ >25 µM)^[1].
ATR-IN-1 (1 h) does not inhibit mTOR signaling in TSC1^−/− MEF cells (IC₅₀ >13 µM)^[1].
ATR-IN-1 has a hERG IC₅₀ >30 µM by automated whole-cell electrophysiology^[1].
ATR-IN-1 does not inhibit CYP3A4, 2D6, 2C9, or 1A2 (IC₅₀ >24 µM)^[1].

Anti-cancer

ATR-IN-1 (72 h) inhibits the growth of ATM-null HT144 melanoma cells with a GI₅₀ of 0.35 µM after 72 h continuous exposure^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1639974-69-8
Molecular Weight 349.40
Formula C₁₈H₁₉N₇O
SMILES

C[C@H]1N(C2=C3C(=CC(=N2)C4=C5C(NC=C5)=CN=N4)N(C)C=N3)CCOC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Barsanti PA, et al. Structure-Based Drug Design of Novel, Potent, and Selective Azabenzimidazoles (ABI) as ATR Inhibitors. ACS medicinal chemistry letters. 2015 Jan 08;6(1):42-6.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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