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Cat. No.: HY-N21677

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Attenuatumione H

Attenuatumione H is a polycyclic polyprenylated acylphloroglucinol compound found in the whole plant of Hypericum attenuatum, and it exhibits antitumor activity. Attenuatumione H exerts cytotoxic effects on liver cancer cells and breast cancer cells. Attenuatumione H shows no significant inhibitory effect on LPS-induced NO production in macrophages and displays no significant cytotoxic activity against osteosarcoma cells. Attenuatumione H can be used in cancer research.

For research use only. We do not sell to patients.

CAS No.: 2172833-78-0
Formula: C₃₅H₅₄O₇
Molecular Weight:586.80

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Attenuatumione H Chemical Structure

CAS No.: 2172833-78-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC50	9.11 mM	Cytotoxicity against human hepatocellular carcinoma Hep-G2 cells incubated for 48 h measured by MTT assay. Cytotoxicity against human hepatocellular carcinoma Hep-G2 cells incubated for 48 h measured by MTT assay.	S187439001630012X
MCF7	IC50	16.24 mM	Cytotoxicity against human breast adenocarcinoma MCF-7 cells incubated for 48 h measured by MTT assay. Cytotoxicity against human breast adenocarcinoma MCF-7 cells incubated for 48 h measured by MTT assay.	S187439001630012X
U2OS	IC50	>50 mM	Cytotoxicity against human osteosarcoma U2OS cells incubated for 48 h measured by MTT assay. Cytotoxicity against human osteosarcoma U2OS cells incubated for 48 h measured by MTT assay.	S187439001630012X
RAW264.7	IC50	>50 mM	Inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 mouse macrophage cells. Inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 mouse macrophage cells.	S187439001630012X

In Vitro

Anti-cancerInnate Immunity

Anti-cancer

Attenuatumione H (compound 2) (48 h) exhibits moderate cytotoxicity against Hep-G2 (IC₅₀ = 9.11 mM) and MCF-7 (IC₅₀ = 16.24 mM) cell lines, but shows no activity against U2OS cells (IC₅₀ > 50 mM)^[1].

Innate Immunity

Attenuatumione H does not inhibit nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells at concentrations up to 50 mM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 2172833-78-0
Molecular Weight 586.80
Formula C₃₅H₅₄O₇
SMILES

CC(C)C([C@]12C3=C(C[C@H](C(C)(O3)C)O)C([C@](C1=O)(C[C@@H]([C@@]2(C)CC/C=C(C)/C)C/C=C(C)\C)C[C@H](O)C(C)(O)C)=O)=O
Structure Classification
- Others
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhou Z B, et al. Cytotoxic polycyclic polyprenylated acylphloroglucinol derivatives and xanthones from Hypericum attenuatum. Phytochemistry Letters, 2016, 15: 215-219.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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