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Cat. No.: HY-N20727

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Austocystins I

Austocystins I is a toxin and protein tyrosine phosphatase inhibitor, with an IC₅₀ of 16 μM against MEG2 and an IC₅₀ of 19 μM against CDC25B. Austocystins I exhibits lethal toxicity to brine shrimp. Austocystins I can be used in the research of cancer and type 2 diabetes.

For research use only. We do not sell to patients.

CAS No.: 58775-51-2
Formula: C₁₈H₁₂O₇
Molecular Weight:340.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Austocystins I Chemical Structure

CAS No.: 58775-51-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

Austocystins I (0.096-200 μg/mL; 24 h) exhibits lethal toxicity towards brine shrimp nauplii with an LC₅₀ of 2.9 μM^[1].
Austocystins I (48 h) does not exhibit significant cytotoxicity towards Vero cells, with a TC₅₀ > 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Metabolic Diseases

Chemical Information

CAS No. 58775-51-2
Molecular Weight 340.28
Formula C₁₈H₁₂O₇
SMILES

O[C@]12C3=C(C4=C(OC5=CC=CC(O)=C5C4=O)C=C3O[C@@]1([H])OC=C2)OC
Structure Classification
- Phenols
- Monophenols
Initial Source
- Microorganisms
Aspergillus puniceus SCSIO z021
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Liang X, et al. Mycotoxins as inhibitors of protein tyrosine phosphatases from the deep-sea-derived fungus Aspergillus puniceus SCSIO z021. Bioorganic chemistry. 2021 Feb;107:104571. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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