Azide-C2-SS-C2-biotin
Based on 1 Customer Validation
Azide-C2-SS-C2-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azide-C2-SS-C2-biotin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Purity : 99.84%
- CAS No.: 1620523-64-9
- Formula: C14H24N6O2S3
- Molecular Weight:404.57
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
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Disulfide Cleavable Linker |
Cleavable Linker |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1620523-64-9
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Appearance Solid
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Molecular Weight 404.57
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Formula C14H24N6O2S3
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Color White to off-white
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SMILES
O=C(NCCSSCCN=[N+]=[N-])CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 25 mg/mL (61.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4718 mL | 12.3588 mL | 24.7176 mL | 61.7940 mL |
| 5 mM | 0.4944 mL | 2.4718 mL | 4.9435 mL | 12.3588 mL | |
| 10 mM | 0.2472 mL | 1.2359 mL | 2.4718 mL | 6.1794 mL | |
| 15 mM | 0.1648 mL | 0.8239 mL | 1.6478 mL | 4.1196 mL | |
| 20 mM | 0.1236 mL | 0.6179 mL | 1.2359 mL | 3.0897 mL | |
| 25 mM | 0.0989 mL | 0.4944 mL | 0.9887 mL | 2.4718 mL | |
| 30 mM | 0.0824 mL | 0.4120 mL | 0.8239 mL | 2.0598 mL | |
| 40 mM | 0.0618 mL | 0.3090 mL | 0.6179 mL | 1.5449 mL | |
| 50 mM | 0.0494 mL | 0.2472 mL | 0.4944 mL | 1.2359 mL | |
| 60 mM | 0.0412 mL | 0.2060 mL | 0.4120 mL | 1.0299 mL |
Azide-C2-SS-C2-biotin Related Classifications
HY-140127 Related Classifications
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