B18 peptide
B18 peptide is a cationic amphipathic α-helical peptidomimetic that binds to the BST-2 extracellular domain and forms a stable complex through intermolecular hydrogen bonds near the N-terminus. B18 peptide competitively inhibits the binding of BST-2 to the extracellular matrix via its extracellular domain, reducing migrasome formation. B18 peptide induces membrane lysis through the formation of pores/water channels and annular pores, impairing membrane integrity. B18 peptide exhibits anticancer activity against breast cancer. B18 peptide can be used for research on breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 3027663-77-7
- Formula: C78H121N23O28S2
- Molecular Weight:1893.06
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
59.8 μM
|
Cytotoxicity against human MCF7 breast cancer cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.
Cytotoxicity against human MCF7 breast cancer cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.
|
32155736 |
| SK-BR-3 | IC50 |
11.2 μM
|
Cytotoxicity against human SKBR3 breast cancer cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.
Cytotoxicity against human SKBR3 breast cancer cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.
|
32155736 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MCF7, SKBR3, MDA-MB-231, MDA-MB-468, T47D, ZR-75-1, and human PBMCs
-
Concentration:0, 0.5, 1.0, 2.1, 4.1, 8.3, 16.5, 33.0, 66.0, 132.0 μM
-
Incubation Time:24 h
-
Result:Reduced cell viability for MCF7 and SKBR3 cell lines with IC50 values of 59.8 μM and 11.2 μM, respectively.
No significant loss of viability was observed for MDA-MB-231, MDA-MB-468, T47D, and ZR-75-1 cell lines, even at the highest concentration tested.
No cytotoxic effect was observed for quiescent human PBMCs; however, at concentrations of 66.0 and 132.0 μM, B18 enhanced cell viability.
Subtle increases in viability were also observed in T47D cells.
Chemical Information
-
CAS No. 3027663-77-7
-
Molecular Weight 1893.06
-
Formula C78H121N23O28S2
-
SMILES
O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CS)C(N[C@@H](CC(N)=O)C(N[C@@H](CC2=CNC=N2)C(N[C@@H]([C@H](O)C)C(N[C@@H](C(C)C)C(N[C@@H](CCSC)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
-
Sequence
Gly-Phe-Gln-Asp-Val-Glu-Ala-Gln-Ala-Ala-Thr-Cys-Asn-His-Thr-Val-Met-Ala
-
Sequence Shortening
GFQDVEAQAATCNHTVMA
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
B18 peptide Related Classifications
HY-P12375 Related Classifications
Powered by Bioz