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Cat. No.: HY-N21781

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Bakkenolide Ia

Bakkenolide Ia is a bakkenolide-type sesquiterpene with antioxidant and free radical scavenging activities. Bakkenolide Ia protects neurons from oxidative damage by inhibiting lipid peroxidation and scavenging free radicals, and improves neuronal cell viability under oxygen-glucose deprivation conditions. Bakkenolide Ia can be used as a neuroprotective agent in oxidative stress-related research and serves as a marker compound for quality evaluation of Petasites species.

For research use only. We do not sell to patients.

CAS No.: 915289-58-6
Formula: C₂₅H₃₄O₆
Molecular Weight:430.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Bakkenolide Ia Chemical Structure

CAS No.: 915289-58-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vitro

Oxidative StressFerroptosis

Oxidative Stress

Bakkenolide Ia (compound 1) (25-100 μg/mL; preincubated for 1 h before 2 h hypoxia, followed by 24 h reoxygenation) exerts a concentration-dependent neuroprotective effect against oxygen-glucose deprivation-induced injury in primary cultured rat cortical neurons, increasing cell viability and reducing LDH release, with cell viability of 68.8% at 100 μg/mL^[1].
Bakkenolide Ia (25-100 μg/mL; co-incubated during oxidative injury, followed by 24 h post-injury incubation) protects primary cultured rat cortical neurons from various oxidative injuries in a concentration-dependent manner, with the strongest effect against Fe²⁺/ascorbic acid-induced injury, achieving a cell survival rate of 87.4% at 100 μg/mL^[1].
Bakkenolide Ia (25-100 μg/mL; 30 min at 37 °C) exhibits concentration-dependent DPPH radical scavenging activity in a cell-free system, with a scavenging rate of 87.3% at 100 μg/mL^[1].

Oxidative Stress

Ferroptosis

Bakkenolide Ia (25-100 μg/mL; 1 h at 37 °C) concentration-dependently inhibits lipid peroxidation in cell-free rat forebrain homogenates, with an inhibition rate of 92.3% at 100 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

primary cultured rat cortical neurons
Concentration:

25, 50, 100 μg/mL
Incubation Time:

1 h pre-incubation prior to 2 h anoxia followed by 24 h re-oxygenation
Result:

Increased cell viability and decreased LDH release, with 68.8% viability at 100 μg/mL.

Related Protocols :

Chemical Information

CAS No. 915289-58-6
Molecular Weight 430.54
Formula C₂₅H₃₄O₆
SMILES

O(C(C=C(C)C)=O)[C@H]1[C@@]2(C[C@@]3(C)[C@@]1([C@@H](OC(C(=CC)C)=O)CC[C@@H]3C)[H])C(=C)COC2=O
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang YL, et al. Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities. Planta medica. 2009 Feb;75(3):230-5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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