Bakkenolide Iva
Bakkenolide Iva is a bakkenolide-type sesquiterpene. Bakkenolide Iva is isolated from the rhizomes of Petasites tricholobus. Bakkenolide Iva inhibits lipid peroxidation in rat brain homogenates and scavenges DPPH free radicals. Bakkenolide Iva protects cortical neurons against oxygen-glucose deprivation-induced injury and oxidative stress-induced neuronal injury. Bakkenolide Iva can be used in research on paralysis and allergic rhinitis.
For research use only. We do not sell to patients.
- CAS No.: 915289-61-1
- Formula: C24H32O6S
- Molecular Weight:448.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
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- References
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Help & FAQs
Biological Activity
Description
In Vitro
Bakkenolide IVa (25-100 μg/mL) significantly protects primary cultured rat cortical neurons against oxidative damage, providing near-complete protection (84.6% viability) against Fe2+/ascorbic acid at 100 μg/mL[1].
Bakkenolide IVa (25-100 μg/mL; 1 h) potently inhibits Fe2+/ascorbic acid-induced lipid peroxidation in rat brain homogenates with a maximal inhibition of 92.5% at 100 μg/mL[1].
Bakkenolide IVa (25-100 μg/mL; 30 min) is an effective DPPH free radical scavenger, reaching 82.7% scavenging activity at 100 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 915289-61-1
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Molecular Weight 448.57
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Formula C24H32O6S
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SMILES
O(C(C=C(C)C)=O)[C@H]1[C@@]2(C[C@@]3(C)[C@@]1([C@@H](OC(C=CSC)=O)CC[C@@H]3C)[H])C(=C)COC2=O
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Wang YL, et al. Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities. Planta medica. 2009 Feb;75(3):230-5. [Content Brief]
[2]. van der Meer JW, et al. Abstract!. The Netherlands journal of medicine. 2002 Dec;60(11):418. [Content Brief]
[3]. Zhang FJ, et al. Anti-allergic effects of total bakkenolides from Petasites tricholobus in ovalbumin-sensitized rats. Phytotherapy research : PTR. 2011 Jan;25(1):116-21. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bakkenolide Iva Related Classifications
HY-N21765 Related Classifications
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