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Cat. No.: HY-184107

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Bcl-2-IN-25

Bcl-2-IN-25 is an orally active Bcl-2 inhibitor that induces cytotoxic activity in cancer cells. Bcl-2-IN-25 can be used in cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 2290611-27-5
Formula: C₄₇H₅₃ClN₈O₈S
Molecular Weight:925.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Bcl-2-IN-25 Chemical Structure

CAS No.: 2290611-27-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Bcl-2-IN-25 is an orally active Bcl-2 inhibitor that induces cytotoxic activity in cancer cells. Bcl-2-IN-25 can be used in cancer-related research^[1].

IC₅₀ & Target

^[1]

Bcl-2

All Bcl-2 Family Isoforms :

In Vitro

Anti-cancer

Bcl-2-IN-25 (Example 9) inhibits viability of human small cell lung carcinoma H146, H889, and H1963 cells with IC₅₀ values of 33 nM, 0.7 nM, and 4.7 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	AUC_last	T_1/2	Bioavailability
Mice^[1]	10 mg/kg	p.o.	8168 ng·h/mL	2.3 h	64 %

In Vivo

Bcl-2-IN-25 (Example 9) (10 mg/kg; single oral gavage administration) exhibits favorable pharmacokinetic profiles in CD-1 mice, with an area under the curve AUC_LAST = 8168 h*ng/mL, an elimination half-life t_1/2 = 2.3 h, and an oral bioavailability of 64%.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 2290611-27-5
Molecular Weight 925.49
Formula C₄₇H₅₃ClN₈O₈S
SMILES

O=S(NC(C1=C(C=C(N2CCN(CC2)CC3=C(C4=CC=C(C=C4)Cl)CC(C)(CC3)C)C=C1)N5C6=C(OCCC5)NC7=NC=CC7=C6)=O)(C8=CC([N+]([O-])=O)=C(C=C8)NC[C@H]9COCCO9)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen Y. Condensed heterocyclic derivatives as bcl-2 inhibitors for the treatment of neoplastic diseases. WO2019040550A1. WIPO; 2019 Feb 28.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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