β-Zearalenol-13C18
β-Zearalenol-13C18 is the 13C-labeled β-Zearalenol (HY-N6741). β-Zearalenol is a zearalenone metabolite and Estrogen receptor binder (Kd = 0.406 nM) that induces apoptosis through activation of p53, JNK, and p38 kinases and the mitochondrial apoptosis pathway, while inhibiting CYP19A1 and inducing autophagy via SIRT1. β-Zearalenol is used in research on cardiotoxicity, mycotoxin-induced reproductive toxicity, and breast cancer.
For research use only. We do not sell to patients.
- Formula: 13C18H24O5
- Molecular Weight:338.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
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Estrogen receptor 0.406 nM (Kd) |
JNK |
p38 |
CYP19A1 |
SIRT1 |
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 71030-11-0
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Molecular Weight 338.25
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Formula 13C18H24O5
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SMILES
O[13C]1=[13C]2[13C](O[13C@H]([13CH2][13CH2][13CH2][13C@H]([13CH2][13CH2][13CH2]/[13CH]=[13CH]/[13C]2=[13CH][13C](O)=[13CH]1)O)[13CH3])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[3]. Yang F, et al. Melatonin alleviates β-zearalenol and HT-2 toxin-induced apoptosis and oxidative stress in bovine ovarian granulosa cells. Environmental toxicology and pharmacology. 2019 May;68:52-60. [Content Brief]
[10]. Tatay E, et al. Estrogenic activity of zearalenone, α-zearalenol and β-zearalenol assessed using the E-screen assay in MCF-7 cells. Toxicology mechanisms and methods. 2018 May;28(4):239-242. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keywords
- β-Zearalenol-13C18
- Isotope-Labeled Compounds
- Drug Metabolite
- Estrogen Receptor/ERR
- MDM-2/p53
- JNK
- p38 MAPK
- Apoptosis
- Cytochrome P450
- Sirtuin
- Autophagy
- RAW264.7 macrophages
- human BeWo cells
- primary bovine ovarian granulosa cells
- Vero cells
- porcine endometrial cells
- human Caco-2 cells
- MCF-7 cells
- H9c2 cells
- HCT116 cells
- human CYP19A1
- Inhibitor
- inhibitor
- inhibit