BI-1607
BI-1607 is a humanized monoclonal antibody targeting FcγRIIB/CD32b. BI-1607 selectively blocks inhibitory FcγRIIB signaling, abrogates its inhibitory function, redirects tumor cell-bound antibodies to activating FcγRs, and its modified Fc region prevents the binding of its own Fc segment to FcγRs. BI-1607 reduces αPD-1 trogocytosis, enhances the effector functions of anti-tumor antibodies (including ADCP and ADCC, promotes intratumoral regulatory T cell (Treg) depletion, myeloid cell reprogramming, induction of interferon-γ (IFN-γ) and CXCL10, and increases the number of activated effector CD8+ T cells. BI-1607 can be used in research related to colorectal cancer, HER2-positive advanced solid tumors, HER2-positive locally advanced or metastatic breast cancer, and HER2-positive metastatic gastric cancer.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Species Reactivity
Human
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FcγRIIB |
CD32b |
αPD-1 |
IFN-γ |
CXCL10 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:B-hCTLA-4 (6-8 week-old, female, 17-20 grams, subcutaneous inoculation of MC38 cells)[1]
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Dosage:10 mg/kg (in combination with 1 mg/kg ipilimumab)
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Administration:i.p.; 3 times on days 1, 4, and 8
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Result:Significantly improved survival compared to ipilimumab alone or BI-1607 alone.
Elevated serum and tumor levels of TNF-α, IFN-γ, and CXCL10 compared to ipilimumab alone.
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Animal Model:hFcγRIIB ± x mFcγRII-/- C57BL/6[2]
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Dosage:10 mg/kg
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Administration:i.v.; single dose
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Result:Showed no significant depletion of B cells 48 hours after administration, compared with pretreatment levels.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Application
ELISA, FACS, Functional assay
Chemical Information
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SMILES
N/A
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Oldham RJ, et al. Tailored FcγR blockade enhances immune checkpoint therapy and overcomes resistance. Journal of experimental & clinical cancer research : CR. 2026 Jul 25;45(1):167. [Content Brief]
[2]. Cortés J, et al. A First-in-Class mAb (BI-1607) Targeting FcγRIIB: Preclinical Data and First-in-Human Studies in Patients with HER2-Positive Advanced Solid Tumors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2025 Dec 01;31(23):4953-4963. [Content Brief]
[5]. Yasuda T, et al. Gastric cancer immunosuppressive microenvironment heterogeneity: implications for therapy development. Trends Cancer. 2024 Jul;10(7):627-642. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BI-1607 Related Classifications
HY-P991582 Related Classifications
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Keywords
- BI-1607
- BI1607
- BI 1607
- Fc Receptor (FcR)
- IFNAR
- PD-1/PD-L1
- CXCR
- colon adenocarcinoma
- ADCP
- ADCC
- colorectal cancer
- HER2-positive metastatic gastric or gastroesophageal junction adenocarcinoma
- gastric cancer
- HER2-positive advanced solid tumors
- FcγRIIB
- HER2-positive locally advanced or metastatic breast cancer
- CD32b
- Inhibitor
- inhibitor
- inhibit