5'-Nucleotidase
Definition:
EC Tree > 3 Hydrolases > 3.1 Acting on ester bonds > 3.1.3 Phosphoric-monoester hydrolases > 3.1.3.5 5'-nucleotidase
5'-Nucleotidase is a broadly specific ectoenzyme that hydrolyses a wide range of 5'-ribonucleotides into the corresponding ribonucleosides and inorganic phosphate. By dephosphorylating extracellular AMP to adenosine, the plasma-membrane GPI-anchored enzyme terminates purinergic signalling, regulates adenosine receptor tone and participates in lymphocyte trafficking and nucleotide salvage. It appears in viruses and cellular organisms and adopts a dimeric HAD-like phosphatase fold.
5'-Nucleotidase is a broadly specific ectoenzyme that hydrolyses a wide range of 5'-ribonucleotides into the corresponding ribonucleosides and inorganic phosphate. By dephosphorylating extracellular AMP to adenosine, the plasma-membrane GPI-anchored enzyme terminates purinergic signalling, regulates adenosine receptor tone and participates in lymphocyte trafficking and nucleotide salvage. It appears in viruses and cellular organisms and adopts a dimeric HAD-like phosphatase fold.
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