7Alpha-hydroxysteroid dehydrogenase
Definition:
EC Tree > 1 Oxidoreductases > 1.1 Acting on the CH-OH group of donors > 1.1.1 With NAD+ or NADP+ as acceptor > 1.1.1.159 7alpha-hydroxysteroid dehydrogenase
7α-hydroxysteroid dehydrogenase catalyzes the oxidation of the 7α-hydroxy group of bile acids and alcohols, both in their free and conjugated forms. Using NAD+, it converts cholate to 3α,12α-dihydroxy-7-oxo-5β-cholan-24-oate, concomitantly reducing NAD+ to NADH and releasing H+; the enzymes from Bacteroides fragilis and Clostridium can also use NADP+. It is found in Eukaryota and Bacteria.
7α-hydroxysteroid dehydrogenase catalyzes the oxidation of the 7α-hydroxy group of bile acids and alcohols, both in their free and conjugated forms. Using NAD+, it converts cholate to 3α,12α-dihydroxy-7-oxo-5β-cholan-24-oate, concomitantly reducing NAD+ to NADH and releasing H+; the enzymes from Bacteroides fragilis and Clostridium can also use NADP+. It is found in Eukaryota and Bacteria.
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