Acetate-CoA ligase

Definition:

EC Tree > 6 Ligases > 6.2 Forming carbon-sulfur bonds > 6.2.1 Acid-thiol ligases > 6.2.1.1 acetate-CoA ligase
Acetate-CoA ligase (acetyl-CoA synthetase) also acts on propanoate and propenoate, activating acetate to acetyl-CoA: ATP and acetate and CoA → AMP and diphosphate and acetyl-CoA, linking acetate to the TCA cycle and fatty-acid synthesis. It appears in viruses and cellular organisms. Structurally it is an acyl-CoA synthetase family enzyme.

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