Acyloxyacyl hydrolase
Definition:
EC Tree > 3 Hydrolases > 3.1 Acting on ester bonds > 3.1.1 Carboxylic-ester hydrolases > 3.1.1.77 acyloxyacyl hydrolase
Acyloxyacyl hydrolase is the leukocyte LPS-detoxifying enzyme. It hydrolyzes the secondary 3-(acyloxy)acyl groups on O-3 of lipid A of Salmonella typhimurium LPS, releasing 3-hydroxyacyl disaccharide and saturated C12-C16 fatty acid, detoxifying endotoxin; it also carries broad phospholipase A1/A2, lysophospholipase and PI-deacylase activities but not triacylglycerols. Expected in Bacteria and Eukaryota.
Acyloxyacyl hydrolase is the leukocyte LPS-detoxifying enzyme. It hydrolyzes the secondary 3-(acyloxy)acyl groups on O-3 of lipid A of Salmonella typhimurium LPS, releasing 3-hydroxyacyl disaccharide and saturated C12-C16 fatty acid, detoxifying endotoxin; it also carries broad phospholipase A1/A2, lysophospholipase and PI-deacylase activities but not triacylglycerols. Expected in Bacteria and Eukaryota.
References:
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