Adamalysin
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.24 Metalloendopeptidases > 3.4.24.46 adamalysin
Horrilysin is a 56-kDa hemorrhagic zinc metalloendopeptidase from the timber rattlesnake (Crotalus horridus horridus) venom that cleaves basement membrane, hide powder and fibrinogen. It cleaves only the single bond Ala14-/-Leu in the insulin B chain, Ser12-/-Leu in the A chain, and Ile-/-Gly, Pro-/-Ala and Ser-/-Trp in melittin. In venom it damages basement membranes. It features an M12-family zinc catalytic domain.
Horrilysin is a 56-kDa hemorrhagic zinc metalloendopeptidase from the timber rattlesnake (Crotalus horridus horridus) venom that cleaves basement membrane, hide powder and fibrinogen. It cleaves only the single bond Ala14-/-Leu in the insulin B chain, Ser12-/-Leu in the A chain, and Ile-/-Gly, Pro-/-Ala and Ser-/-Trp in melittin. In venom it damages basement membranes. It features an M12-family zinc catalytic domain.
References:
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