Adenosylcobinamide-phosphate synthase
Definition:
EC Tree > 6 Ligases > 6.3 Forming carbon-nitrogen bonds > 6.3.1 Acid—ammonia (or amine) ligases (amide synthases) > 6.3.1.10 adenosylcobinamide-phosphate synthase
Adenosylcobinamide-phosphate synthase amidates adenosylcobyric acid with (R)-1-aminopropan-2-yl phosphate to form adenosylcobinamide phosphate: ATP plus adenosylcobyric acid plus (R)-1-aminopropan-2-yl phosphate yields ADP plus phosphate plus adenosylcobinamide phosphate; the (R)-1-aminopropan-2-yl alcohol can also substitute, yielding adenosylcobinamide. The aminopropanol phosphate is produced by CobD (EC 4.1.1.81 threonine-phosphate decarboxylase). It is found in Bacteria and Archaea. Structurally it is a CbiB-type amidoligase.
Adenosylcobinamide-phosphate synthase amidates adenosylcobyric acid with (R)-1-aminopropan-2-yl phosphate to form adenosylcobinamide phosphate: ATP plus adenosylcobyric acid plus (R)-1-aminopropan-2-yl phosphate yields ADP plus phosphate plus adenosylcobinamide phosphate; the (R)-1-aminopropan-2-yl alcohol can also substitute, yielding adenosylcobinamide. The aminopropanol phosphate is produced by CobD (EC 4.1.1.81 threonine-phosphate decarboxylase). It is found in Bacteria and Archaea. Structurally it is a CbiB-type amidoligase.
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