Alcohol dehydrogenase
Definition:
EC Tree > 1 Oxidoreductases > 1.1 Acting on the CH-OH group of donors > 1.1.1 With NAD+ or NADP+ as acceptor > 1.1.1.1 alcohol dehydrogenase
Alcohol dehydrogenase is a zinc-containing oxidoreductase that uses NAD+ as acceptor and oxidizes primary alcohols to the corresponding aldehydes, secondary alcohols to the corresponding ketones, and also acts on hemiacetals; it displays very broad substrate specificity, although it oxidizes methanol much less efficiently than ethanol. The animal form (but not the yeast enzyme) additionally acts on cyclic secondary alcohols. In its reactions it converts (R)-mevalonate to mevaldate and likewise oxidizes generic primary and secondary alcohols, in each case reducing NAD+ to NADH and releasing H+. The enzyme is distributed across Eukaryota, Bacteria and Archaea.
Alcohol dehydrogenase is a zinc-containing oxidoreductase that uses NAD+ as acceptor and oxidizes primary alcohols to the corresponding aldehydes, secondary alcohols to the corresponding ketones, and also acts on hemiacetals; it displays very broad substrate specificity, although it oxidizes methanol much less efficiently than ethanol. The animal form (but not the yeast enzyme) additionally acts on cyclic secondary alcohols. In its reactions it converts (R)-mevalonate to mevaldate and likewise oxidizes generic primary and secondary alcohols, in each case reducing NAD+ to NADH and releasing H+. The enzyme is distributed across Eukaryota, Bacteria and Archaea.
References:
Biomedical Dictionary
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