Alpha-glucosidase
Definition:
EC Tree > 3 Hydrolases > 3.2 Glycosylases > 3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds > 3.2.1.20 alpha-glucosidase
Alpha-glucosidase is a broad exo-glycosidase that hydrolyses terminal non-reducing (1->4)-linked alpha-D-glucose residues, releasing D-glucose; specificity is directed mainly at exohydrolysis of (1->4)-alpha-glucosidic linkages, hydrolysing oligosaccharides rapidly and polysaccharides slowly or not at all, and it can also hydrolyse (1->6)-alpha-D-glucose links more slowly; the intestinal enzyme also hydrolyses polysaccharides similarly to glucan 1,4-alpha-glucosidase (EC 3.2.1.3) but releases alpha- rather than beta-glucose. By digesting dietary starch oligosaccharides it acts at the small-intestinal brush border. It is distributed across Eukaryota, Bacteria and Archaea.
Alpha-glucosidase is a broad exo-glycosidase that hydrolyses terminal non-reducing (1->4)-linked alpha-D-glucose residues, releasing D-glucose; specificity is directed mainly at exohydrolysis of (1->4)-alpha-glucosidic linkages, hydrolysing oligosaccharides rapidly and polysaccharides slowly or not at all, and it can also hydrolyse (1->6)-alpha-D-glucose links more slowly; the intestinal enzyme also hydrolyses polysaccharides similarly to glucan 1,4-alpha-glucosidase (EC 3.2.1.3) but releases alpha- rather than beta-glucose. By digesting dietary starch oligosaccharides it acts at the small-intestinal brush border. It is distributed across Eukaryota, Bacteria and Archaea.
References:
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