Anthranilate synthase
Definition:
EC Tree > 4 Lyases > 4.1 Carbon-carbon lyases > 4.1.3 Oxo-acid-lyases > 4.1.3.27 anthranilate synthase
Anthranilate synthase is a two-component C-C lyase in the shikimate pathway. It is composed of a glutaminase subunit that produces ammonia from L-glutamine, and a lyase subunit that channels the ammonia to chorismate, converting chorismate together with L-glutamine into anthranilate, pyruvate and L-glutamate; in the absence of glutaminase it can use free NH3. It is found in plants, fungi and bacteria, and in some organisms is part of a multifunctional protein together with other shikimate-pathway enzymes. It is feedback-regulated by tryptophan. Structurally it is a chorismate-utilizing (ACT-domain) anthranilate synthase.
Anthranilate synthase is a two-component C-C lyase in the shikimate pathway. It is composed of a glutaminase subunit that produces ammonia from L-glutamine, and a lyase subunit that channels the ammonia to chorismate, converting chorismate together with L-glutamine into anthranilate, pyruvate and L-glutamate; in the absence of glutaminase it can use free NH3. It is found in plants, fungi and bacteria, and in some organisms is part of a multifunctional protein together with other shikimate-pathway enzymes. It is feedback-regulated by tryptophan. Structurally it is a chorismate-utilizing (ACT-domain) anthranilate synthase.
References:
Biomedical Dictionary
The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.
Molarity Calculator
Dilution Calculator
