Apyrase
Definition:
EC Tree > 3 Hydrolases > 3.6 Acting on acid anhydrides > 3.6.1 In phosphorus-containing anhydrides > 3.6.1.5 apyrase
Apyrase is a soluble or ecto-nucleotidase found in viruses and cellular organisms; it acts on both NDPs and NTPs, hydrolyzing NTPs to NMPs in two successive phosphate-releasing steps with NDPs as intermediates, and differs from ATPases by acting on both ATP and ADP; eukaryotic enzymes require Ca2+ though Mg2+ can substitute, and most cell-surface ecto-ATPases belong to this family. It hydrolyzes NDP into NMP and phosphate, and NTP into NDP and phosphate, further to NMP and 2 phosphate. In extracellular nucleotide clearance it degrades ATP/ADP. It requires Ca2+.
Apyrase is a soluble or ecto-nucleotidase found in viruses and cellular organisms; it acts on both NDPs and NTPs, hydrolyzing NTPs to NMPs in two successive phosphate-releasing steps with NDPs as intermediates, and differs from ATPases by acting on both ATP and ADP; eukaryotic enzymes require Ca2+ though Mg2+ can substitute, and most cell-surface ecto-ATPases belong to this family. It hydrolyzes NDP into NMP and phosphate, and NTP into NDP and phosphate, further to NMP and 2 phosphate. In extracellular nucleotide clearance it degrades ATP/ADP. It requires Ca2+.
References:
Biomedical Dictionary
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