Archaeosine synthase
Definition:
EC Tree > 2 Transferases > 2.6 Transferring nitrogenous groups > 2.6.1 Transaminases > 2.6.1.97 archaeosine synthase
Archaeosine synthase is a tRNA-modifying amidinotransferase. In Euryarchaeota it is ArcS; in Crenarchaeota lacking ArcS it is carried by a glutaminase-domain-containing 7-cyano-7-deazaguanine synthase (EC 6.3.4.20) or a preQ1 synthase (EC 1.7.1.13) homologue. It transfers the amidino group from L-glutamine onto the 7-cyano-7-carbaguanine15 of tRNA, hydrolyzing glutamine to glutamate and water and forming archaeine15. The Methanocaldococcus jannaschii enzyme also uses arginine and ammonium. It occurs in Archaea, Eukaryota and Bacteria.
Archaeosine synthase is a tRNA-modifying amidinotransferase. In Euryarchaeota it is ArcS; in Crenarchaeota lacking ArcS it is carried by a glutaminase-domain-containing 7-cyano-7-deazaguanine synthase (EC 6.3.4.20) or a preQ1 synthase (EC 1.7.1.13) homologue. It transfers the amidino group from L-glutamine onto the 7-cyano-7-carbaguanine15 of tRNA, hydrolyzing glutamine to glutamate and water and forming archaeine15. The Methanocaldococcus jannaschii enzyme also uses arginine and ammonium. It occurs in Archaea, Eukaryota and Bacteria.
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